ArticleBMC infectious diseases2014
Streptococcus agalactiae in Brazil: serotype distribution, virulence determinants and antimicrobial susceptibility.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.
- Global patterns of antibiotic resistance in group BFrontiers in microbiology · 2025Pooled it
- Streptococcus agalactiae carriage among pregnant women living in Rio de Janeiro, Brazil, over a period of eight years.PloS one · 2018Trial
- Temporal trends in Group B Streptococcus colonization, serotype distribution, and antimicrobial resistance among pregnant women in the Brazilian Amazon across the COVID-19 pandemic, 2018-2023.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Dairy FarmPathogens (Basel, Switzerland) · 2026Article
- Phenotypic and genotypic characterization of ST103 serotype Ia Streptococcus agalactiae isolated from bovine mastitis in China.BMC microbiology · 2025Article
- Capsule typing and clonal relationships of group B streptococci isolated from male patients diagnosed with urinary tract infection.Folia microbiologica · 2025Article
- High prevalence of penicillin-resistant group B Streptococcus among pregnant women in Northwest Ethiopia.Scientific reports · 2025Article
- Serotype distribution, virulence factors, and antimicrobial resistance profiles of Streptococcus agalactiae (Group B Streptococcus) isolated from pregnant women in the Brazilian Amazon.BMC microbiology · 2025Article
- Genomic characterization of group BMicrobial genomics · 2025Article
- Genomic features and pathogenic potential ofJournal of advanced veterinary and animal research · 2025Article
- Article
- A Comparative Analysis of Molecular Epidemiology and Antibiotic Resistance in Group B Streptococcus Isolated From Invasive and Noninvasive Adult Cases in Daejeon, South Korea.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Article
- Genotype Distribution and Antibiotic Susceptibility Pattern of Clinical Isolates of Group BJournal of tropical medicine · 2023Article
- Changes in Group BPathogens (Basel, Switzerland) · 2022Article
- Genetic diversity and antimicrobial resistance of invasive, noninvasive and colonizing group BAccess microbiology · 2022Article
- Whole genome sequence based capsular typing and antimicrobial resistance prediction of Group B streptococcal isolates from colonized pregnant women in Nigeria.BMC genomics · 2021Article
- Antimicrobial Resistance among Beta-HemolyticAntibiotics (Basel, Switzerland) · 2021Review
- Phylogeny, recombination, and invasiveness of group B Streptococcus revealed by genomic comparisons of its global strains.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Streptococcus agalactiae strains isolated from cancer patients in Rio de Janeiro, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Prevalence, serotypes and virulence genes of Streptococcus agalactiae isolated from pregnant women with 35-37 weeks of gestation.BMC infectious diseases · 2021Article
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Authors and funding
27 authors at 13 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGroup B Streptococcus (GBS) remains a major cause of neonatal sepsis and is also associated with invasive and noninvasive infections in pregnant women and non-pregnant adults, elderly and patients with underlying medical conditions. Ten capsular serotypes have been recognized, and determination of their distribution within a specific population or geographical region is important as they are major targets for the development of vaccine strategies. We have evaluated the characteristics of GBS isolates recovered from individuals with infections or colonization by this microorganism, living in different geographic regions of Brazil.
methodsA total of 434 isolates were identified and serotyped by conventional phenotypic tests. The determination of antimicrobial susceptibility was performed by the disk diffusion method. Genes associated with resistance to erythromycin (ermA, ermB, mefA) and tetracycline (tetK, tetL, tetM, tetO) as well as virulence-associated genes (bac, bca, lmb, scpB) were investigated using PCR. Pulsed-field gel electrophoresis (PFGE) was used to examine the genetic diversity of macrolide-resistant and of a number of selected macrolide-susceptible isolates.
resultsOverall, serotypes Ia (27.6%), II (19.1%), Ib (18.7%) and V (13.6%) were the most predominant, followed by serotypes IV (8.1%) and III (6.7%). All the isolates were susceptible to the beta-lactam antimicrobials tested and 97% were resistant to tetracycline. Resistance to erythromycin and clindamycin were found in 4.1% and 3% of the isolates, respectively. Among the resistance genes investigated, tetM (99.3%) and tetO (1.8%) were detected among tetracycline-resistant isolates and ermA (39%) and ermB (27.6%) were found among macrolide-resistant isolates. The lmb and scpB virulence genes were detected in all isolates, while bac and bca were detected in 57 (13.1%) and 237 (54.6%) isolates, respectively. Molecular typing by PFGE showed that resistance to erythromycin was associated with a variety of clones.
conclusionThese findings indicate that GBS isolates circulating in Brazil have a variety of phenotypic and genotypic characteristics, and suggest that macrolide-resistant isolates may arise by both clonal spread and independent acquisition of resistance genes.
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