ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2014
Simultaneous detection of nucleic acid and protein using gold nanoparticles and lateral flow device.
Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Advancements in Nanomaterial-Based Biosensors for Neuropsychiatric and Neurodegenerative Diagnostics: From Biomarker Discovery to Clinical Translation.Biosensors · 2026Review
- Simultaneous Rapid Nucleic Acid and Protein Detection in a Lateral Chromatography Chip for COVID-19 Diagnosis.ACS omega · 2022Article
- Oxide Nanowire Microfluidic Devices for Capturing Single-stranded DNAs.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021Article
- Obtaining Specific Sequence Tags forPathogens (Basel, Switzerland) · 2021Article
- Use of nanotechnology for infectious disease diagnostics: application in drug resistant tuberculosis.BMC infectious diseases · 2019Article
- The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation.Nanomaterials (Basel, Switzerland) · 2018Review
- Universal Biotin-PEG-Linked Gold Nanoparticle Probes for the Simultaneous Detection of Nucleic Acids and Proteins.Bioconjugate chemistry · 2017Article
- Gold Nanoparticle Based Platforms for Circulating Cancer Marker Detection.Nanotheranostics · 2017Article
- Ultrasensitive, rapid and inexpensive detection of DNA using paper based lateral flow assay.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In this work, we present a simple and fast approach for simultaneous detection of nucleic acid and protein using gold nanoparticles (GNPs) and a lateral flow device (LFD). Sandwich-type immunoreactions and DNA hybridizations were performed simultaneously on the LFD by using DNA- and antibody-functionalized GNPs. The captured GNPs, due to the DNA hybridization and immunoreaction events on the LFD, produced characteristic red bands that could be used for the qualitative detections of DNA and/or protein. The proof of principle was demonstrated by using 60-mer DNA and rabbit IgG (R-IgG) model targets. The LFD was capable of detecting a minimum of 0.5 nM target DNA and 2 ng mL(-1) IgG simultaneously in 15 min. The proposed LFD shows great promise for in-field and point-of-care testing of disease-related circulating nucleic acid and protein biomarkers in biological fluids.
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Registered trials
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