Evidence map›Paper›PMID 24919565›Full record

ArticleInternational journal of obesity (2005)2015

Changes in morphology and function of adrenal cortex in mice fed a high-fat diet.

M M Swierczynska, I Mateska, M Peitzsch, S R Bornstein, T Chavakis, G Eisenhofer, V Lamounier-Zepter, S Eaton

Open access · bronzeAbstract read
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In one paragraph

Article in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Lipid metabolism in the adrenal gland.Frontiers in endocrinology · 2025
    Review
  3. The Potential of DehydratedPharmaceuticals (Basel, Switzerland) · 2024
    Article
  4. Article
  5. Article
  6. Review
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  14. Review
  15. High-Fat Diet Feeding Alters Expression of Hepatic Drug-Metabolizing Enzymes in Mice.Drug metabolism and disposition: the biological fate of chemicals · 2017
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

M M Swierczynska1] Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany [2] Department of Internal Medicine III, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
I Mateska1] Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany [2] Department of Internal Medicine III, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
M PeitzschDepartment of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
S R BornsteinDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
T ChavakisDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
G EisenhoferDepartment of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
V Lamounier-ZepterDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
S EatonMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
University Hospital Carl Gustav Carus · DEMax Planck Society · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesObesity is a major risk factor for the development of type 2 diabetes and other debilitating diseases. Obesity and diabetes are intimately linked with altered levels of adrenal steroids. Elevated levels of these hormones induce insulin resistance and cause cardiovascular diseases. The mechanisms underlying obesity-related alterations in adrenal steroids are still not well understood. Here, we investigated how diet-induced obesity affects the morphology and function of the mouse adrenal cortex.

methodsWe fed animals either a high-fat diet (HFD) or a normal diet (60% kcal from fat or 10% kcal from fat, respectively) for 18 weeks. We then assessed various aspects of adrenal gland morphology and function, as well as basal plasma concentrations of steroid hormones and ACTH.

resultsWe show that adrenal glands of mice fed a HFD release more corticosterone and aldosterone, resulting in higher plasma levels. This increase is driven by adrenal cortical hyperplasia, and by increased expression of multiple genes involved in steroidogenesis. We demonstrate that diet-induced obesity elevates Sonic hedgehog signaling in Gli1-positive progenitors, which populate the adrenal capsule and give rise to the steroidogenic cells of the adrenal cortex. Feeding animals with a HFD depletes Gli1-positive progenitors, as the adrenal cortex expands.

conclusionsThis work provides insight into how diet-induced obesity changes the biology of the adrenal gland. The association of these changes with increased Shh signaling suggests possible therapeutic strategies for obesity-related steroid hormone dysfunction.

Indexed as

Adrenal CortexAdrenal Cortex HormonesAnimalsCells, CulturedCorticosteroneDiet, High-FatDisease Models, AnimalHeat-Shock ProteinsHedgehog ProteinsKruppel-Like Transcription FactorsMiceMice, Inbred C57BLMice, KnockoutObesityZinc Finger Protein GLI1Adrenal Cortex HormonesCorticosteroneGli1 protein, mouseHeat-Shock ProteinsHedgehog ProteinsKruppel-Like Transcription FactorsShh protein, mouseZinc Finger Protein GLI1

Identifiers

PMID24919565
OpenAlexW2030746825

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.