Evidence map›Paper›PMID 24918984›Full record

ArticleJournal of pediatric gastroenterology and nutrition2014

Race affects outcome among infants with intestinal failure.

Robert H Squires, Jane Balint, Simon Horslen, Paul W Wales, Jason Soden, Christopher Duggan, Ruosha Li, Steven H Belle, Pediatric Intestinal Failure Consortium

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. The Development of the International Intestinal Failure Registry and an Overview of its Results.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2024
    Review
  6. Article
  7. Glimmers of hope for intestinal transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  8. Article
  9. Article
  10. Review
  11. Racial disparity in placental pathology in the collaborative perinatal project.International journal of clinical and experimental pathology · 2015
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Robert H Squires*Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA †Nationwide Children's Hospital, Columbus, OH ‡Seattle Children's Hospital, Seattle, WA §The Hospital for Sick Children, Toronto, Ontario, Canada ||Children's Hospital Colorado Medical Center, Denver ¶Boston Children's Hospital, Boston, MA #Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Jane Balint
Simon Horslen
Paul W Wales
Jason Soden
Christopher Duggan
Ruosha Li
Steven H Belle
Pediatric Intestinal Failure Consortium
University of Pittsburgh · USBoston Children's Hospital · USChildren's Hospital Colorado · USChildren's Hospital of Pittsburgh · USHospital for Sick Children · CANationwide Children's Hospital · USSeattle Children's Hospital · US

Funding

Neurogenin3 and Intestinal FailureR01DK083762 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, MARTIN G · 2009 to 2012
$1.6M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24HD058795 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2010 to 2014
$956k
Intestinal failure in children: A contemporary retrospective review by the PediatR21DK081059 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SQUIRES, ROBERT H · 2008 to 2009
$473k
NICHD NIH HHS K24 HD058795NIDDK NIH HHS 1 R21 DK081059-01NIDDK NIH HHS R01 DK083762NIDDK NIH HHS R21 DK081059
6 · The paper itself

Abstract

objectiveIntestinal failure (IF) is a rare, devastating condition associated with significant morbidity and mortality. We sought to determine whether ethnic and racial differences were associated with patient survival and likelihood of receiving an intestinal transplant in a contemporary cohort of children with IF.

methodsThis was an analysis of a multicenter cohort study with data collected from chart review conducted by the Pediatric Intestinal Failure Consortium. Entry criteria included infants ≤ 12 months receiving parenteral nutrition (PN) for ≥ 60 continuous days and studied for at least 2 years. Outcomes included death and intestinal transplantation (ITx). Race and ethnicity were recorded as they were in the medical record. For purposes of statistical comparisons and regression modeling, categories of race were consolidated into "white" and "nonwhite" children.

resultsOf 272 subjects enrolled, 204 white and 46 nonwhite children were available for analysis. The 48-month cumulative incidence probability of death without ITx was 0.40 for nonwhite and 0.16 for white children (P < 0.001); the cumulative incidence probability of ITx was 0.07 for nonwhite versus 0.31 for white children (P = 0.003). The associations between race and outcomes remained after accounting for low birth weight, diagnosis, and being seen at a transplant center.

conclusionsRace is associated with death and receiving an ITx in a large cohort of children with IF. This study highlights the need to investigate reasons for this apparent racial disparity in outcome among children with IF.

Indexed as

Racial GroupsCohort StudiesFemaleHumansInfantIntestinal DiseasesIntestinesMaleRetrospective Studies

Identifiers

PMID24918984
PMCPMC4176512
OpenAlexW2001788967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.