ArticleBritish journal of cancer2014
Characterisation of familial colorectal cancer Type X, Lynch syndrome, and non-familial colorectal cancer.
Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Hereditary Colorectal Cancer: From Diagnosis to Surgical Options.Clinics in colon and rectal surgery · 2025Review
- Inherited BRCA1 and RNF43 pathogenic variants in a familial colorectal cancer type X family.Familial cancer · 2024Article
- From APC to the genetics of hereditary and familial colon cancer syndromes.Human molecular genetics · 2021Review
- Deciding the operation type according to mismatch repair status among hereditary nonpolyposis colorectal cancer patients: should a tailored approach be applied, or does one size fit all?Hereditary cancer in clinical practice · 2021Article
- Discovering the Mutational Profile of Early Colorectal Lesions: A Translational Impact.Cancers · 2021Review
- Associations of Height With the Risks of Colorectal and Endometrial Cancer in Persons With Lynch Syndrome.American journal of epidemiology · 2021Article
- Pathogenic Germline Mutations of DNA Repair Pathway Components in Early-Onset Sporadic Colorectal Polyp and Cancer Patients.Cancers · 2020Article
- Different surgical outcome and follow-up status between dMMR and pMMR colorectal cancer patients who fulfilled with Amsterdam-II criteria.World journal of surgical oncology · 2020Article
- Broadening risk profile in familial colorectal cancer type X; increased risk for five cancer types in the national Danish cohort.BMC cancer · 2020Article
- Patterns of germline and somatic mutations in 16 genes associated with mismatch repair function or containing tandem repeat sequences.Cancer medicine · 2020Article
- Novel candidates in early-onset familial colorectal cancer.Familial cancer · 2020Article
- Targeted next generation sequencing screening of Lynch syndrome in Tunisian population.Familial cancer · 2019Article
- Risk of multiple colorectal cancer development depends on age and subgroup in individuals with hereditary predisposition.Familial cancer · 2019Article
- Phenotypic and genotypic heterogeneity of Lynch syndrome: a complex diagnostic challenge.Familial cancer · 2018Review
- Cohort Profile: The Colon Cancer Family Registry Cohort (CCFRC).International journal of epidemiology · 2018Article
- Hereditary Nonpolyposis Colorectal Cancer and Cancer Syndromes: Recent Basic and Clinical Discoveries.Journal of oncology · 2018Review
- Familial Colorectal Cancer Type X.Current genomics · 2017Review
- Familial Colorectal Cancer Type X in Central Iran: A New Clinicopathologic Description.International journal of hematology-oncology and stem cell research · 2017Article
- 2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications.Oncotarget · 2017Review
- Review
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18 authors.
Funding
Abstract
backgroundFamilial Colorectal Cancer Type X (FCCTX) is defined as individuals with colorectal cancer (CRC) who families meet Amsterdam Criteria-1 (AC1), but whose tumours are DNA-mismatch-repair-proficient, unlike Lynch syndrome (LS). FCCTX does not have an increased risk of extra-colonic cancers. This analysis compares epidemiologic and clinicopathologic features among FCCTX, LS, and 'non-familial' (non-AC1) CRC cases.
methodsFrom the Colon Cancer Family Registry, FCCTX (n=173), LS (n=303), and non-AC1 (n=9603) CRC cases were identified. Questionnaire-based epidemiologic information and CRC pathologic features were compared across case groups using polytomous logistic regression.
resultsCompared with LS, FCCTX cases were less likely to be current (vs never) smokers; have a proximal subsite (vs rectal) tumour; or have mucinous histology, poor differentiation, or tumour-infiltrating lymphocytes. There were no observed differences in co-morbidities or medication usage.
conclusionsFCCTX were less likely to be current tobacco users; other exposures were similar between these groups. Histopathologic differences highly suggestive of LS CRCs do not appear to be shared by FCCTX.
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