Evidence map›Paper›PMID 24918769›Full record

ArticlePloS one2014

Discovery and characterization of distinct simian pegiviruses in three wild African Old World monkey species.

Samuel D Sibley, Michael Lauck, Adam L Bailey, David Hyeroba, Alex Tumukunde, Geoffrey Weny, Colin A Chapman, David H O'Connor, Tony L Goldberg, Thomas C Friedrich

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Viruses in sanctuary chimpanzees across Africa.American journal of primatology · 2023
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  4. Review
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  15. Genome Sequence of a Novel Kunsagivirus (Genome announcements · 2017
    Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Samuel D SibleyDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Michael LauckDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Adam L BaileyDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
David HyerobaMakerere University, Kampala, Uganda.
Alex TumukundeMakerere University, Kampala, Uganda.
Geoffrey WenyMakerere University, Kampala, Uganda.
Colin A ChapmanMakerere University, Kampala, Uganda; Department of Anthropology and McGill School of Environment, Montreal, Quebec, Canada.
David H O'ConnorDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America; Wisconsin National Primate Research Center, Madison, Wisconsin, United States of America.
Tony L GoldbergDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America; Makerere University, Kampala, Uganda; Wisconsin National Primate Research Center, Madison, Wisconsin, United States of America.
Thomas C FriedrichDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America; Wisconsin National Primate Research Center, Madison, Wisconsin, United States of America.
University of Wisconsin–Madison · USMakerere University · UGMcGill University · CA

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 1985 to 2011
$106.7M
INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Defining the importance of CD8+ T Cell Breadth in SIV/HIV protective immunityR01AI084787 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI FRIEDRICH, THOMAS C., O'CONNOR, DAVID H. · 2009 to 2013
$3.2M
Biological and Human Dimensions of Primate Retroviral TransmissionR01AI098420 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDBERG, TONY L. · 2011 to 2015
$2.3M
Graduate Training In Cellular And Molecular Pathogenesis Of Human DiseasesT32GM081061 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FABRY, ZSUZSANNA · 2010 to 2019
$1.8M
The Impact and Society Ecology of Bacterial Zoonoses in Northern Tanzania: UnderR01TW009237 · FIC · DUKE UNIVERSITY · PI CRUMP, JOHN ANDREW · 2011 to 2014
$1.7M
FIC NIH HHS R01 TW009237FIC NIH HHS TW009237NCRR NIH HHS P51 RR000167NIAID NIH HHS R01 AI084787NIAID NIH HHS R01 AI098420NIGMS NIH HHS T32 GM008692NIGMS NIH HHS T32 GM081061NIH HHS P51 OD011106
6 · The paper itself

Abstract

Within the Flaviviridae, the recently designated genus Pegivirus has expanded greatly due to new discoveries in bats, horses, and rodents. Here we report the discovery and characterization of three simian pegiviruses (SPgV) that resemble human pegivirus (HPgV) and infect red colobus monkeys (Procolobus tephrosceles), red-tailed guenons (Cercopithecus ascanius) and an olive baboon (Papio anubis). We have designated these viruses SPgVkrc, SPgVkrtg and SPgVkbab, reflecting their host species' common names, which include reference to their location of origin in Kibale National Park, Uganda. SPgVkrc and SPgVkrtg were detected in 47% (28/60) of red colobus and 42% (5/12) red-tailed guenons, respectively, while SPgVkbab infection was observed in 1 of 23 olive baboons tested. Infections were not associated with any apparent disease, despite the generally high viral loads observed for each variant. These viruses were monophyletic and equally divergent from HPgV and pegiviruses previously identified in chimpanzees (SPgVcpz). Overall, the high degree of conservation of genetic features among the novel SPgVs, HPgV and SPgVcpz suggests conservation of function among these closely related viruses. Our study describes the first primate pegiviruses detected in Old World monkeys, expanding the known genetic diversity and host range of pegiviruses and providing insight into the natural history of this genus.

Indexed as

AnimalsCercopithecusColobusFlaviviridaeGenome, ViralMonkey DiseasesPapio anubisPhylogeny

Identifiers

PMID24918769
PMCPMC4053331
OpenAlexW1988202421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.