ArticlePloS one2014
HIVE-hexagon: high-performance, parallelized sequence alignment for next-generation sequencing data analysis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
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- GII.17 norovirus re-emerged in the 2020s as a result of dynamic and adaptive evolutionary processes.Nature communications · 2025Article
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- Higher levels of Bifidobacteria and tumor necrosis factor in children with drug-resistant epilepsy are associated with anti-seizure response to the ketogenic diet.EBioMedicine · 2022Observational
- Stable Cell Clones Harboring Self-Replicating SARS-CoV-2 RNAs for Drug Screen.Journal of virology · 2022Article
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- Mice with dysfunctional TGF-β signaling develop altered intestinal microbiome and colorectal cancer resistant to 5FU.Biochimica et biophysica acta. Molecular basis of disease · 2021Article
- Bioinformatics tools developed to support BioCompute Objects.Database : the journal of biological databases and curation · 2021Article
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- Mutated CEACAMs Disrupt Transforming Growth Factor Beta Signaling and Alter the Intestinal Microbiome to Promote Colorectal Carcinogenesis.Gastroenterology · 2020Article
- Baseline human gut microbiota profile in healthy people and standard reporting template.PloS one · 2019Article
- Article
- A complete Leishmania donovani reference genome identifies novel genetic variations associated with virulence.Scientific reports · 2018Article
- Complete Genome Sequence of a Nontypeable GII Norovirus Detected in Peru.Genome announcements · 2018Article
- Separation and assembly of deep sequencing data into discrete sub-population genomes.Nucleic acids research · 2017Article
- Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization.Scientific reports · 2017Article
- High-performance integrated virtual environment (HIVE): a robust infrastructure for next-generation sequence data analysis.Database : the journal of biological databases and curation · 2016Article
- Generation and propagation of recombinant mumps viruses exhibiting an additional U residue in the homopolymeric U tract of the F gene-end signal.Virus genes · 2015Article
- Design and development of a medical big data processing system based on Hadoop.Journal of medical systems · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
unlabelledDue to the size of Next-Generation Sequencing data, the computational challenge of sequence alignment has been vast. Inexact alignments can take up to 90% of total CPU time in bioinformatics pipelines. High-performance Integrated Virtual Environment (HIVE), a cloud-based environment optimized for storage and analysis of extra-large data, presents an algorithmic solution: the HIVE-hexagon DNA sequence aligner. HIVE-hexagon implements novel approaches to exploit both characteristics of sequence space and CPU, RAM and Input/Output (I/O) architecture to quickly compute accurate alignments. Key components of HIVE-hexagon include non-redundification and sorting of sequences; floating diagonals of linearized dynamic programming matrices; and consideration of cross-similarity to minimize computations. AVAILABILITY: https://hive.biochemistry.gwu.edu/hive/
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.