ArticleNutrients2014
Vitamin D level and risk of community-acquired pneumonia and sepsis.
Article in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 7 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Assessment of the influence of vitamin D in patients with sepsis: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- The Vitamin D Serum Levels in Pregnant Women Affected by COVID-19: A Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- Association between micronutrient deficiency and acute respiratory infections in healthy adults: a systematic review of observational studies.Nutrition journal · 2019Pooled it
- The association between vitamin D deficiency and community-acquired pneumonia: A meta-analysis of observational studies.Medicine · 2019Pooled it
- Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2019Pooled it
- Community-onset sepsis and its public health burden: a systematic review.Systematic reviews · 2016Pooled it
- Significant association between vitamin D deficiency and sepsis: a systematic review and meta-analysis.BMC anesthesiology · 2015Pooled it
- Effect of adjunctive single high-dose vitamin DScientific reports · 2018Trial
- Vitamin D Deficiency at Hospital Admission With Community-Acquired Pneumonia is Associated With Increased Risk of Mortality: A Prospective Cohort Study.Open forum infectious diseases · 2025Article
- 25-hydroxyvitamin D and parathyroid hormone in new onset sepsis: A prospective study in critically ill patients.Metabolism open · 2024Article
- Prevalence of vitamin D deficiency and associated risk of all-cause and cause-specific mortality among middle-aged and older adults in the United States.Frontiers in nutrition · 2023Article
- Baseline Levels of Vitamin D in a Healthy Population from a Region with High Solar Irradiation.Nutrients · 2021Article
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- Serum Vitamin D Level and Risk of Community-Acquired Pneumonia: A Case-Control Study.Interdisciplinary perspectives on infectious diseases · 2021Article
- Vitamin D Deficiency is Associated with Increased Use of Antimicrobials among Preschool Girls in Ethiopia.Nutrients · 2019Article
- Reduced Vitamin D Levels are Associated with Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke.Clinical interventions in aging · 2019Article
- Association between serum 25-hydroxyvitamin D concentration and pulmonary infection in children.Medicine · 2018Observational
- Vitamin D status and its influence on outcomes following major burn injury and critical illness.Burns & trauma · 2018Review
- 25(OH)D and 1,25(OH)D vitamin D fails to predict sepsis and mortality in a prospective cohort study.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Previous research has reported reduced serum 25-hydroxyvitamin D (25(OH)D) levels is associated with acute infectious illness. The relationship between vitamin D status, measured prior to acute infectious illness, with risk of community-acquired pneumonia (CAP) and sepsis has not been examined. Community-living individuals hospitalized with CAP or sepsis were age-, sex-, race-, and season-matched with controls. ICD-9 codes identified CAP and sepsis; chest radiograph confirmed CAP. Serum 25(OH)D levels were measured up to 15 months prior to hospitalization. Regression models adjusted for diabetes, renal disease, and peripheral vascular disease evaluated the association of 25(OH)D levels with CAP or sepsis risk. A total of 132 CAP patients and controls were 60 ± 17 years, 71% female, and 86% Caucasian. The 25(OH)D levels <37 nmol/L (adjusted odds ratio (OR) 2.57, 95% CI 1.08-6.08) were strongly associated with increased odds of CAP hospitalization. A total of 422 sepsis patients and controls were 65 ± 14 years, 59% female, and 91% Caucasian. The 25(OH)D levels <37 nmol/L (adjusted OR 1.75, 95% CI 1.11-2.77) were associated with increased odds of sepsis hospitalization. Vitamin D status was inversely associated with risk of CAP and sepsis hospitalization in a community-living adult population. Further clinical trials are needed to evaluate whether vitamin D supplementation can reduce risk of infections, including CAP and sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.