ArticleMetabolic syndrome and related disorders2014
The "metabolic winter" hypothesis: a cause of the current epidemics of obesity and cardiometabolic disease.
Article in Metabolic syndrome and related disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Melatonin Supplementation and Anthropometric Indices: A Randomized Double-Blind Controlled Clinical Trial.BioMed research international · 2021Trial
- Photoperiod-Dependent Effects of Phenolic-Enriched Fruit Extracts on Postprandial Triacylglyceride Levels and Acute Inflammatory Responses in F344 Rats.Molecular nutrition & food research · 2025Article
- Seasonal Patterns in Erectile Dysfunction Severity.Cureus · 2025Article
- A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency.Frontiers in public health · 2020Review
- Chronic lifestyle diseases display seasonal sensitive comorbid trend in human population evidence from Google Trends.PloS one · 2018Article
- Synchronic inverse seasonal rhythmus of energy density of food intake and sleep quality: a contribution to chrono-nutrition from a Polish adult population.European journal of clinical nutrition · 2017Article
- Plant-based nutrition for healthcare professionals: implementing diet as a primary modality in the prevention and treatment of chronic disease.Journal of geriatric cardiology : JGC · 2017Review
- Response to: "If the Metabolic Winter Is Coming, When Will It Be Summer?" (Metab Syndr Relat Disord 2017;15:3).Metabolic syndrome and related disorders · 2017Article
- Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease.Metabolic syndrome and related disorders · 2017Review
- Cortisol dysregulation in obesity-related metabolic disorders.Current opinion in endocrinology, diabetes, and obesity · 2015Review
- Effects of low-stearate palm oil and high-stearate lard high-fat diets on rat liver lipid metabolism and glucose tolerance.Nutrition & metabolism · 2015Article
- Resveratrol use in metabolic syndrome.Metabolic syndrome and related disorders · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The concept of the "Calorie" originated in the 1800 s in an environment with limited food availability, primarily as a means to define economic equivalencies in the energy density of food substrates. Soon thereafter, the energy densities of the major macronutrients-fat, protein, and carbohydrates-were defined. However, within a few decades of its inception, the "Calorie" became a commercial tool for industries to promote specific food products, regardless of health benefit. Modern technology has altered our living conditions and has changed our relationship with food from one of survival to palatability. Advances in agriculture, food manufacturing, and processing have ensured that calorie scarcity is less prevalent than calorie excess in the modern world. Yet, many still approach dietary macronutrients in a reductionist manner and assume that isocalorie foodstuffs are isometabolic. Herein, we discuss a novel way to view the major food macronutrients and human diet in this era of excessive caloric consumption, along with a novel relationship among calorie scarcity, mild cold stress, and sleep that may explain the increasing prevalence of nutritionally related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.