ArticleTransplantation2014
The combined risk of donor quality and recipient age: higher-quality kidneys may not always improve patient and graft survival.
Article in Transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Favorable Adherence and Tolerability of Letermovir Versus Valganciclovir for Cytomegalovirus Prophylaxis in Kidney Transplant Recipients Aged 65 y or Older: Findings From a Randomized, Phase 3 Trial.Transplantation direct · 2026Article
- Eligibility, timing, and organ quality: indications and outcomes of kidney transplantation in older patients.Kidney international · 2026Review
- Kidney Donor Risk Index and Cardiovascular Complications in a Long-Term Follow-Up Observation.Journal of clinical medicine · 2025Article
- Kidney Donor Profile Index and allograft outcomes: interactive effects of estimated post-transplant survival score and ischaemic time.Clinical kidney journal · 2023Article
- Impact of acute kidney injury in deceased donors with high Kidney Donor Profile Index on posttransplant clinical outcomes: a multicenter cohort study.Kidney research and clinical practice · 2021Article
- Histological and clinical evaluation of marginal donor kidneys before transplantation: Which is best?World journal of transplantation · 2019Review
- Reevaluation of the Kidney Donor Risk Index.Transplantation · 2019Article
- Article
- Increasing kidney donor profile index sequence does not adversely affect medium-term health-related quality of life after kidney transplantation.Clinical transplantation · 2018Article
- Is the Kidney Donor Risk Index a Useful Tool in Non-US Patients?Canadian journal of kidney health and disease · 2018Article
- Strategies for an Expanded Use of Kidneys From Elderly Donors.Transplantation · 2017Review
- Waiting for a Deceased Kidney Donor Transplant: Better a Small Fish Than an Empty Dish?Clinical journal of the American Society of Nephrology : CJASN · 2016Article
- National outcomes of kidney transplantation from deceased diabetic donors.Kidney international · 2015Article
- Influence of Deceased Donor and Pretransplant Recipient Parameters on Early Overall Kidney Graft-Survival in Germany.Journal of transplantation · 2015Article
- Transplantation: to accept, or not to accept-that is the question.Nature reviews. Nephrology · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe Kidney Donor Profile Index (KDPI) is a more precise donor organ quality metric replacing age-based characterization of donor risk. Little prior attention has been paid on the outcomes of lower-quality kidneys transplanted into elderly recipients. Although we have previously shown that immunological risks associated with older organs are attenuated by advanced recipient age, it remains unknown whether risks associated with lower-quality KDPI organs are similarly reduced in older recipients.
methodsDonor organ quality as measured by the KDPI was divided into quintiles (very high, high, medium, low, and very low quality), and Cox proportional hazards was used to assess graft and recipient survival in first-time adult deceased donor transplant recipients by recipient age.
resultsIn uncensored graft survival analysis, recipients older than 69 years had demonstrated comparable outcomes if they received low-quality kidneys compared to medium-quality kidneys. Death-censored analysis demonstrated no increased relative risk when low-quality kidneys were transplanted into recipients aged 70 to 79 years (hazard ratio [HR], 1.11; P=0.19) or older than 79 years (HR, 1.08; P=0.59). In overall survival analysis, elderly recipients gained no relative benefit from medium-quality kidneys over low-quality kidneys (70-79 years: HR, 1.03, P=0.51; >79 years: HR, 1.08; P=0.32).
conclusionOur analysis demonstrates that transplanting medium-quality kidneys into elderly recipients does not provide significant advantage over low-quality kidneys.
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