ReviewPediatrics2014
Treatment setting, clinical trial enrollment, and subsequent outcomes among adolescents with cancer: a literature review.
Review in Pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Abatement of the Survival Cliff in Older Adolescents and Young Adults with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma in the United States.Journal of adolescent and young adult oncology · 2025Article
- Closing the gap: proposing a socio-ecological framework to make cancer clinical trials more accessible, equitable, and acceptable to adolescents and young adults.The oncologist · 2024Article
- Future of Treatment of Adolescents and Young Adults With ALL: A Vision for Collaboration and Equity.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Review
- NCI intramural program approach to rare tumors: Natural history study of rare solid tumors in children and adults: A longitudinal, comprehensive data and biospecimen collection protocol.Pediatric blood & cancer · 2023Article
- Genomic disparities between cancers in adolescent and young adults and in older adults.Nature communications · 2022Article
- Review
- A Hope-Based Intervention to Address Disrupted Goal Pursuits and Quality of Life Among Young Adult Cancer Survivors.Journal of cancer education : the official journal of the American Association for Cancer Education · 2020Article
- EORTC SPECTA-AYA: A unique molecular profiling platform for adolescents and young adults with cancer in Europe.International journal of cancer · 2020Article
- Neuro-oncology in adolescents and young adults-an unmet need.Neuro-oncology · 2020Article
- Gynecological cancer among adolescents and young adults (AYA).Annals of translational medicine · 2020Review
- Enrollment of adolescents and young adults onto SWOG cancer research network clinical trials: A comparative analysis by treatment site and era.Cancer medicine · 2020Article
- Access to Clinical Trials for Adolescents and Young Adults With Cancer: A Meta-Research Analysis.JNCI cancer spectrum · 2019Article
- Adolescent angst: enrollment on clinical trials.Hematology. American Society of Hematology. Education Program · 2018Review
- Role of clinical trials in survival progress of American adolescents and young adults with cancer-and lack thereof.Pediatric blood & cancer · 2018Article
- Observational
- Geographic Access to Cancer Care and Mortality Among Adolescents.Journal of adolescent and young adult oncology · 2018Article
- Observational
- Transforming geographic scale: a comparison of combined population and areal weighting to other interpolation methods.International journal of health geographics · 2017Article
- Enrolling Adolescents in Disease/Target-Appropriate Adult Oncology Clinical Trials of Investigational Agents.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- Early discharge as a mediator of greater ICU-level care requirements in patients not enrolled on the AAML0531 clinical trial: a Children's Oncology Group report.Cancer medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThere has been an overall improvement in survival rates for persons with cancer over the past 35 years. However, these gains are less prevalent among adolescents with cancer aged 15 to 19 years, which may be due to lower clinical trial enrollment among adolescents with cancer.
methodsWe conducted a literature review to assess current research regarding clinical trial enrollment and subsequent outcomes among adolescents with cancer. The search included English-language publications that reported original data from January 1985 to October 2011.
resultsThe search identified 539 records. Of these 539 records, there were 30 relevant original research articles. Multiple studies reported that adolescents with cancer are enrolled in clinical trials at lower rates compared with younger children and older adults. Treatment setting, physician type, and institution type may all be factors in the low enrollment rate among adolescents. Few data focused solely on adolescents, with many studies combining adolescents with young adults. The number of available studies related to this topic was limited, with significant variability in study design, methods, and outcomes.
conclusionsThis literature review suggests that adolescents with cancer are not treated at optimal settings and are enrolled in clinical trials at low rates. This may lead to inferior treatment and poor subsequent medical and psychosocial outcomes. The scarcity in data further validates the need for additional research focusing on this population.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.