Evidence map›Paper›PMID 24918169›Full record

ArticleAge and ageing2014

Relationships between physical performance and knee and hip osteoarthritis: findings from the European Project on Osteoarthritis (EPOSA).

Mark H Edwards, Suzan van der Pas, Michael Dieter Denkinger, Camille Parsons, Karen A Jameson, Laura Schaap, Sabina Zambon, Maria-Victoria Castell, Florian Herbolsheimer, Hans Nasell and 9 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Age and ageing, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07471204 (Muscle Oxygenation and Recovery Dynamics in Individuals With Knee Osteoarthritis), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07471204 completednot on this mapstarted 2026, after this paper: background citation

Muscle Oxygenation and Recovery Dynamics in Individuals With Knee Osteoarthritis: A Case-Control Study

TypeobservationalSponsorBahçeşehir UniversityRan2026 to 2026Enrolled34ConditionsOsteoarthritis of Knee, Healthy ParticipantsArmsNo intervention
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

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  8. The Effect of the Mixed Extract ofCurrent issues in molecular biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 7 countries.

Mark H EdwardsMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Suzan van der PasVU University Medical Centre, Amsterdam, Netherlands.
Michael Dieter DenkingerBethesda Geriatrische Klinik, Ulm, Germany.
Camille ParsonsMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Karen A JamesonMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Laura SchaapVU University Medical Centre, Amsterdam, Netherlands.
Sabina ZambonDepartment of Medical and Surgical Sciences, University of Padova, Padova, Italy.
Maria-Victoria CastellDepartment of Preventive Medicine and Public Health, Universidad Autonoma de Madrid, Madrid, Spain.
Florian HerbolsheimerBethesda Geriatrische Klinik, Ulm, Germany.
Hans NasellDepartment of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden.
Mercedes Sanchez-MartinezDepartment of Preventive Medicine and Public Health, Universidad Autonoma de Madrid, Madrid, Spain.
Angel OteroDepartment of Preventive Medicine and Public Health, Universidad Autonoma de Madrid, Madrid, Spain.
Thorsten NikolausBethesda Geriatrische Klinik, Ulm, Germany.
Natasja M van SchoorVU University Medical Centre, Amsterdam, Netherlands.
Nancy L PedersenDepartment of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden.
Stefania MaggiDepartment of Medical and Surgical Sciences, University of Padova, Padova, Italy.
Dorly J H DeegVU University Medical Centre, Amsterdam, Netherlands.
Cyrus CooperMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Elaine DennisonMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Amsterdam UMC Location VUmc · NLAgaplesion Bethesda Klinik · DEMRC Lifecourse Epidemiology Unit · GBUniversidad Autónoma de Madrid · ESKarolinska Institutet · SEUniversity of Padua · ITUniversity of Southampton · GB

Funding

Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1015Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2
6 · The paper itself

Abstract

backgroundpoor physical performance (PP) is known to be associated with disability, lower quality of life and higher mortality rates. Knee and hip osteoarthritis (OA) might be expected to contribute to poor PP, through joint pain and restricted range of movement. Both clinical and self-reported OA are often used for large-scale community and epidemiological studies.

objectiveto examine the relationships between hip and knee OA and PP in a large data set comprising cohorts from six European countries.

methodsa total of 2,942 men and women aged 65-85 years from the Germany, Italy, Netherlands, Spain, Sweden and the UK were recruited. Assessment included an interview and clinical assessment for OA. PP was determined from walking speed, chair rises and balance (range 0-12); low PP was defined as a score of ≤9.

resultsthe mean (SD) age was 74.2 (5.1) years. Rates of self-reported OA were much higher than clinical OA. Advanced age, female gender, lower educational attainment, abstinence from alcohol and higher body mass index were independently associated with low PP. Clinical knee OA, hip OA or both were associated with a higher risk of low PP; OR (95% CI) 2.93 (2.36, 3.64), 3.79 (2.49, 5.76) and 7.22 (3.63, 14.38), respectively, with relationships robust to adjustment for the confounders above as well as pain.

conclusionlower limb OA at the hip and knee is associated with low PP, and for clinical diagnosis relationships are robust to adjustment for pain. Those at highest risk have clinical OA at both sites.

Indexed as

Health StatusAgedAged, 80 and overArthralgiaChi-Square DistributionEuropeFemaleGaitHealth SurveysHumansLogistic ModelsMaleOdds RatioOsteoarthritis, HipOsteoarthritis, KneePhysical ExaminationEuropeanolder peopleosteoarthritisphysical performanceprevalence

Identifiers

PMID24918169
PMCPMC4207630
OpenAlexW2100786525

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.