ArticleFrontiers in oncology2014
Extramedullary acute myeloid leukemia: leukemic pleural effusion, case report and review of the literature.
Article in Frontiers in oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Rare presentation of serous effusions in pediatric acute myeloid leukemia: insights from a retrospective case series.BMC pediatrics · 2026Article
- Fluid-Derived Organoids from Pleural Effusion and Ascites: Emerging Models for Drug Resistance and Personalized Oncology.Journal of Cancer · 2026Review
- An Unusual Case of Effusive-Constrictive Pericarditis in the Intensive Care Unit.CASE (Philadelphia, Pa.) · 2022Article
- Acute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: A case report and review of literature.Open medicine (Warsaw, Poland) · 2021Article
- Polyserositis as a primary clinical manifestation of CD7+ acute myelogenous leukemia with myeloid sarcoma: A case report.Medicine · 2020Article
- Intrapleural cisplatin for management of malignant pleural effusion in a patient with plasma cell leucaemia.BMJ case reports · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objective and importanceMalignant pleural effusions occur in the setting of both solid and hematologic malignancies. Pleural effusion caused by leukemic infiltration is an unusual extramedullary manifestation of acute myeloid leukemia (AML) with fewer than 20 cases reported (1-11). We report a case of pericardial and pleural effusions in a patient with AML and review the literature. CLINICAL PRESENTATION: In this case, a 55-year-old man with previous history of myeloproliferative neoplasm experienced transformation AML, heralded by appearance of leukemic pleural effusions. The patient was identified to have leukemic pleural effusion based on the extended cytogenetic analysis of the pleural fluid, as morphologic analysis alone was insufficient.
interventionThe patient was treated with hypomethylator-based and intensive chemotherapy strategies, both of which maintained resolution of the effusions in the remission setting.
conclusionDue to the rarity of diagnosis of leukemic pleural effusions, both cytogenetic and fluorescence in situ hybridization testing are recommended. Furthermore, systemic chemotherapy directed at the AML can lead to complete resolution of leukemic pleural effusions.
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