Evidence map›Paper›PMID 24918049›Full record

ArticleFEBS open bio2014

Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling.

Prasanna K Santhekadur, Maaged Akiel, Luni Emdad, Rachel Gredler, Jyoti Srivastava, Devaraja Rajasekaran, Chadia L Robertson, Nitai D Mukhopadhyay, Paul B Fisher, Devanand Sarkar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

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  7. Molecular docking andRSC advances · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Prasanna K SanthekadurDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States.
Maaged AkielDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States.
Luni EmdadDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States.
Rachel GredlerDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States.
Jyoti SrivastavaDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States.
Devaraja RajasekaranDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States.
Chadia L RobertsonDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States.
Nitai D MukhopadhyayDepartment of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298, United States.
Paul B FisherDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States ; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, United States ; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, VA 23298, United States.
Devanand SarkarDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States ; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, United States ; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, VA 23298, United States.
Virginia Commonwealth University · US

Funding

Analysis of a novel regulator of hepatocellular carcinomaR01CA138540 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SARKAR, DEVANAND · 2010 to 2014
$1.6M
AEG-1: Novel Gene Involved in Malignant GliomaR01CA134721 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI FISHER, PAUL B · 2009 to 2013
$1.5M
NCI NIH HHS R01 CA134721NCI NIH HHS R01 CA138540
6 · The paper itself

Abstract

Staphylococcal nuclease domain containing-1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) patients and promotes tumorigenesis by human HCC cells. We now document that SND1 increases angiotensin II type 1 receptor (AT1R) levels by increasing AT1R mRNA stability. This results in activation of ERK, Smad2 and subsequently the TGFβ signaling pathway, promoting epithelial-mesenchymal transition (EMT) and migration and invasion by human HCC cells. A positive correlation was observed between SND1 and AT1R expression levels in human HCC patients. Small molecule inhibitors of SND1, alone or in combination with AT1R blockers, might be an effective therapeutic strategy for late-stage aggressive HCC.

Indexed as

ACE, angiotensin-I converting enzymeACE-I, ACE inhibitorsAT1RAT1R, angiotensin II type 1 receptorEMT, epithelial–mesenchymal transitionFDR, false discovery rateHCC, human hepatocellular carcinomaInvasionLP, losartan potassiumMTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideNASH, non-alcoholic steatohepatitisPAI-1PAI-1, plasminogen activator inhibitor-1RISC, RNA-induced silencing complexSND1SND1, Staphylococcal nuclease domain containing-1TGFβ

Identifiers

PMID24918049
PMCPMC4050181
OpenAlexW1998364925

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.