ArticleUnited European gastroenterology journal2014
Fructose transporters GLUT5 and GLUT2 expression in adult patients with fructose intolerance.
Article in United European gastroenterology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- GLUT5: structure, functions, diseases and potential applications.Acta biochimica et biophysica Sinica · 2023Review
- Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do not contribute to clinical presentation of acquired fructose malabsorption.BMC gastroenterology · 2022Article
- A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine : "A gut feeling".Cellular and molecular life sciences : CMLS · 2020Review
- Glucose transporters in the small intestine in health and disease.Pflugers Archiv : European journal of physiology · 2020Review
- Article
- UEG Week 2019 Poster Presentations.United European gastroenterology journal · 2019Article
- Dapagliflozin Prevents NOX- and SGLT2-Dependent Oxidative Stress in Lens Cells Exposed to Fructose-Induced Diabetes Mellitus.International journal of molecular sciences · 2019 · on this mapArticle
- Intestinal Absorption of Fructose.Annual review of nutrition · 2018Review
- ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome.Metabolism: clinical and experimental · 2018Article
- Identification of essential amino acids for glucose transporter 5 (GLUT5)-mediated fructose transport.The Journal of biological chemistry · 2018Article
- Current and emergent pharmacologic treatments for irritable bowel syndrome with diarrhea: evidence-based treatment in practice.Therapeutic advances in gastroenterology · 2017Review
- Fibromyalgia Syndrome: A Metabolic Approach Grounded in Biochemistry for the Remission of Symptoms.Frontiers in medicine · 2017Article
- The sedentary (r)evolution: Have we lost our metabolic flexibility?F1000Research · 2017Article
- Fructose malabsorption.Molecular and cellular pediatrics · 2016Article
- Use of the Biphasic (13)C-Sucrose/Glucose Breath Test to Assess Sucrose Maldigestion in Adults with Functional Bowel Disorders.BioMed research international · 2016Article
- Dietary sugars: their detection by the gut-brain axis and their peripheral and central effects in health and diseases.European journal of nutrition · 2015Review
- Fructose-induced symptoms beyond malabsorption in FGID.United European gastroenterology journal · 2014Article
- Dietary fructose intolerance, fructan intolerance and FODMAPs.Current gastroenterology reports · 2014Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastrointestinal symptoms and malabsorption following fructose ingestion (fructose intolerance) are common in functional gastrointestinal disorders (FGID). The underlying mechanism is unclear, but is hypothesized to be related an abnormality of intestinal fructose transporter proteins.
objectiveTo assess the expression of the main intestinal fructose transporter proteins, glucose transport protein 5 (GLUT5) and 2 (GLUT2), in FGID.
methodsThe expression of GLUT5 and GLUT2 protein and mRNA in small intestinal biopsy tissue was investigated using real-time reverse-transcription PCR and Western immunoblotting in 11 adults with FGID and fructose intolerance ascertained by breath testing and in 15 controls.
resultsMedian expression levels of GLUT5 mRNA normalized to beta-actin were 0.18 (interquartile range, IQR, 0.13-0.21) in patients and 0.17 (IQR 0.12-0.19) in controls (p > 0.05). Respective levels of GLUT2 mRNA were 0.26 (IQR 0.20-0.31) and 0.26 (IQR 0.19-0.31) (p > 0.05). Median expression levels of GLUT5 protein normalized to alpha-tubulin were 0.95 (IQR 0.52-1.68) in patients and 0.95 (IQR 0.59-1.15) in controls (p > 0.05). Respective protein expression levels for GLUT2 were 1.56 (IQR 1.06-2.14) and 1.35 (IQR 0.96-1.79) (p > 0.05).
conclusionsHuman fructose intolerance may not be associated with marked changes in GLUT5 and GLUT2 expression. Replication of these results in a larger subject group, including measures of transporter activation and membrane and subcellular localization, is warranted.
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