ArticleUnited European gastroenterology journal2013
Serological testing for celiac disease in adults.
Article in United European gastroenterology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling.Health technology assessment (Winchester, England) · 2022Pooled it
- Systematic review with meta-analysis: the accuracy of serological tests to support the diagnosis of coeliac disease.Alimentary pharmacology & therapeutics · 2022Pooled it
- Identifying Key Biomarkers in Celiac Disease through Analysis of Microarray Data.Journal of medical signals and sensors · 2025Article
- Mode of presentation and performance of serology assays for diagnosing celiac disease: A single-center study in the United Arab Emirates.Frontiers in nutrition · 2023Article
- Celiac Disease Revisited.GE Portuguese journal of gastroenterology · 2022Review
- Humoral immune response to COVID-19 infection or vaccination among celiac disease patients.Central-European journal of immunology · 2022Article
- Classification of intestinal T-cell receptor repertoires using machine learning methods can identify patients with coeliac disease regardless of dietary gluten status.The Journal of pathology · 2021Article
- Evaluation of the Utility of Amino Acid Citrulline as a Surrogate Metabolomic Biomarker for the Diagnosis of Celiac Disease.Nutrition and metabolic insights · 2021Article
- Celiac disease and Sjögren's syndrome: A case report and review of literature.World journal of clinical cases · 2020Article
- Development of an administrative definition for celiac disease.BMC research notes · 2019Article
- Diagnostic Yield of Isolated Deamidated Gliadin Peptide Antibody Elevation for Celiac Disease.Digestive diseases and sciences · 2017Article
- The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes.Przeglad gastroenterologiczny · 2016Article
- The relation between celiac disease, nonceliac gluten sensitivity and irritable bowel syndrome.Nutrition journal · 2015Review
- Prevalence estimation of celiac disease in the general adult population of Latvia using serology and HLA genotyping.United European gastroenterology journal · 2015Article
- Diagnostic performances of celiac disease serological tests among Saudi patients.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- Evaluation of the Relationship Between Celiac Disease and Refractory Epilepsy in Patients Referring to Imam Khomeini Hospital, Urmia.Basic and clinical neuroscienceArticle
- The Progression of Celiac Disease, Diagnostic Modalities, and Treatment Options.Journal of investigative medicine high impact case reportsReview
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2 authors.
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Abstract
BACKGROUND AND
aimWe present a systematic review on the performance of currently available methods for serological diagnosis of celiac disease (CD) and the role of human leukocyte antigen (HLA) typing.
objectiveA literature survey was conducted using PubMed, MeSH database, Web of Science as well as manual searches.
resultsTissue transglutaminase antibodies (tTG) (IgA) (tested in nine studies) show sensitivities and specificities in the range of 0.76-0.968 and 0.909-0.98, and deamidated gliadin peptide (DGP) (IgA and IgG) (tested in eight studies) show sensitivities and specificities in the range of 0.69-0.984 and 0.903-1. Endomysial antibodies (EMA) (tested in five studies) show sensitivities and specificities in the range of 0.61-0.937 and 0.98-1, respectively. Combination assays (tested in three studies) using DGP + tTG and DGP (IgA + IgG) show sensitivities and specificities in the range of 0.87-1 and 0.8-1, respectively. HLA DQ2/DQ8 may be necessary for the development of CD-HLA DQ2 in particular. A possible close correlation may also exist between CD and HLA-G.
conclusionDGP and tTG for serological testing for CD show equivalent diagnostic performance. More studies with, in particular, DGP alone and in combination with tTG are necessary before a firm recommendation can be made. HLA typing to exclude CD may still be controversial. It still seems premature to diagnose celiac disease in adults based on serology alone.
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