ArticleFrontiers in neuroanatomy2014
Trajectory of the main GABAergic interneuron populations from early development to old age in the rat primary auditory cortex.
Article in Frontiers in neuroanatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 87 citations in OpenAlex.
- Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Developmental trajectories of somatostatin-positive interneurons in the human auditory cortex from migration to maturation.Communications biology · 2026Article
- Presynaptic control of top-down signaling in neocortical layer 1.bioRxiv : the preprint server for biology · 2026Article
- Oral Supplementation With a Bovine Thymus Extract Reduces Neuronal Excitability in Aging Mice.FASEB bioAdvances · 2026Article
- Chronic nicotine reverses age-related decline of interneuron markers in mouse auditory cortex.Frontiers in aging neuroscience · 2026Article
- Intranasal Insulin Mitigates Memory Impairment and Neuroinflammation in a Mouse Model of Hippocampal Aging.Pharmacology research & perspectives · 2025Article
- Mechanisms of auditory enhancement in younger and older adults.The Journal of the Acoustical Society of America · 2025Article
- "Surviving and Thriving": evidence for cortical GABA stabilization in cognitively-intact oldest-old adults.Translational psychiatry · 2025Article
- Article
- Differential Encoding of Two-Tone Harmonics in the Male and Female Mouse Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- DISSECT: deep semi-supervised consistency regularization for accurate cell type fraction and gene expression estimation.Genome biology · 2024Article
- Cardiometabolic health, menopausal estrogen therapy and the brain: How effects of estrogens diverge in healthy and unhealthy preclinical models of aging.Frontiers in neuroendocrinology · 2023Review
- Information Encoding in Bursting Spiking Neural Network Modulated by Astrocytes.Entropy (Basel, Switzerland) · 2023Article
- Age-related changes in excitatory and inhibitory intra-cortical circuits in auditory cortex of C57Bl/6 mice.Hearing research · 2023Article
- The local and long-range input landscape of inhibitory neurons in mouse auditory cortex.The Journal of comparative neurology · 2023Article
- Three-dimensional mapping in multi-samples with large-scale imaging and multiplexed post staining.Communications biology · 2023Article
- Age-related central gain with degraded neural synchrony in the auditory brainstem of mice and humans.Neurobiology of aging · 2022Article
- Constrained brain volume in an efficient coding model explains the fraction of excitatory and inhibitory neurons in sensory cortices.PLoS computational biology · 2022Article
- How Staying Negative Is Good for the (Adult) Brain: Maintaining Chloride Homeostasis and the GABA-Shift in Neurological Disorders.Frontiers in molecular neuroscience · 2022Review
- Altered Response Dynamics and Increased Population Correlation to Tonal Stimuli Embedded in Noise in Aging Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In both humans and rodents, decline in cognitive function is a hallmark of the aging process; the basis for this decrease has yet to be fully characterized. However, using aged rodent models, deficits in auditory processing have been associated with significant decreases in inhibitory signaling attributed to a loss of GABAergic interneurons. Not only are these interneurons crucial for pattern detection and other large-scale population dynamics, but they have also been linked to mechanisms mediating plasticity and learning, making them a prime candidate for study and modeling of modifications to cortical communication pathways in neurodegenerative diseases. Using the rat primary auditory cortex (A1) as a model, we probed the known markers of GABAergic interneurons with immunohistological methods, using antibodies against gamma aminobutyric acid (GABA), parvalbumin (PV), somatostatin (SOM), calretinin (CR), vasoactive intestinal peptide (VIP), choline acetyltransferase (ChAT), neuropeptide Y (NPY), and cholecystokinin (CCK) to document the changes observed in interneuron populations across the rat's lifespan. This analysis provided strong evidence that several but not all GABAergic neurons were affected by the aging process, showing most dramatic changes in expression of parvalbumin (PV) and somatostatin (SOM) expression. With this evidence, we show how understanding these trajectories of cell counts may be factored into a simple model to quantify changes in inhibitory signaling across the course of life, which may be applied as a framework for creating more advanced simulations of interneuronal implication in normal cerebral processing, normal aging, or pathological processes.
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