ArticleFrontiers in neural circuits2014
Acute modulation of synaptic plasticity of pyramidal neurons by activin in adult hippocampus.
Article in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Tonic activin signaling shapes cellular and synaptic properties of CA1 neurons mainly in dorsal hippocampus.iScience · 2023Article
- Dorsal-Ventral Gradient of Activin Regulates Strength of GABAergic Inhibition along Longitudinal Axis of Mouse Hippocampus in an Activity-Dependent Fashion.International journal of molecular sciences · 2023Article
- Neurotrophic Factors and Dendritic Spines.Advances in neurobiology · 2023Article
- Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization.The EMBO journal · 2022Article
- Dysregulation ofLearning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- An exon junction complex-independent function of Barentsz in neuromuscular synapse growth.EMBO reports · 2022Article
- Neuroadaptations and TGF-β signaling: emerging role in models of neuropsychiatric disorders.Molecular psychiatry · 2022Review
- Activin A Reduces GIRK Current to Excite Dentate Gyrus Granule Cells.Frontiers in cellular neuroscience · 2022Article
- Hippocampal plasticity may drive cocaine relapse.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson's Disease.International journal of molecular sciences · 2020Review
- Knockdown of microRNA-17-5p Enhances the Neuroprotective Effect of Act A/Smads Signal Loop After Ischemic Injury.Neurochemical research · 2019Article
- Learning induces the translin/trax RNase complex to express activin receptors for persistent memory.eLife · 2017Article
- Activin A is increased in the nucleus accumbens following a cocaine binge.Scientific reports · 2017Article
- A calpain-2 selective inhibitor enhances learning & memory by prolonging ERK activation.Neuropharmacology · 2016Article
- Noncanonical Activin A Signaling in PC12 Cells: A Self-Limiting Feedback Loop.Neurochemical research · 2016Article
- Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated Mechanisms.Frontiers in cellular neuroscience · 2016Article
- Activin Signaling in the Pathogenesis and Therapy of Neuropsychiatric Diseases.Frontiers in molecular neuroscience · 2016Review
- Chronic Noise Exposure Acts Cumulatively to Exacerbate Alzheimer's Disease-Like Amyloid-β Pathology and Neuroinflammation in the Rat Hippocampus.Scientific reports · 2015Article
- A key role for TGF-β1 in hippocampal synaptic plasticity and memory.Scientific reports · 2015Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activin A is known as a neuroprotective factor produced upon acute excitotoxic injury of the hippocampus (in pathological states). We attempt to reveal the role of activin as a neuromodulator in the adult male hippocampus under physiological conditions (in healthy states), which remains largely unknown. We showed endogenous/basal expression of activin in the hippocampal neurons. Localization of activin receptors in dendritic spines (=postsynapses) was demonstrated by immunoelectron microscopy. The incubation of hippocampal acute slices with activin A (10 ng/mL, 0.4 nM) for 2 h altered the density and morphology of spines in CA1 pyramidal neurons. The total spine density increased by 1.2-fold upon activin treatments. Activin selectively increased the density of large-head spines, without affecting middle-head and small-head spines. Blocking Erk/MAPK, PKA, or PKC prevented the activin-induced spinogenesis by reducing the density of large-head spines, independent of Smad-induced gene transcription which usually takes more than several hours. Incubation of acute slices with activin for 2 h induced the moderate early long-term potentiation (moderate LTP) upon weak theta burst stimuli. This moderate LTP induction was blocked by follistatin, MAPK inhibitor (PD98059) and inhibitor of NR2B subunit of NMDA receptors (Ro25-6981). It should be noted that the weak theta burst stimuli alone cannot induce moderate LTP. These results suggest that MAPK-induced phosphorylation of NMDA receptors (including NR2B) may play an important role for activin-induced moderate LTP. Taken together, the current results reveal interesting physiological roles of endogenous activin as a rapid synaptic modulator in the adult hippocampus.
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