Evidence map›Paper›PMID 24917661›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2014

The influence of ART on the treatment of Trichomonas vaginalis among HIV-infected women.

Alys Adamski, Rebecca A Clark, Leandro Mena, Harold Henderson, Judy Levison, Norine Schmidt, Hirut T Gebrekristos, David H Martin, Patricia Kissinger

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. PersistentInternational journal of STD & AIDS · 2020
    Article
  3. Review
  4. Epidemiology and treatment of trichomoniasis.Current infectious disease reports · 2015
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Alys AdamskiDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Rebecca A ClarkDepartment of Medicine, Louisiana State University, New Orleans.
Leandro MenaDepartment of Medicine, University of Mississippi Medical Center, Jackson.
Harold HendersonDepartment of Medicine, University of Mississippi Medical Center, Jackson.
Judy LevisonBaylor College of Medicine, Houston, Texas.
Norine SchmidtDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Hirut T GebrekristosDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
David H MartinDepartment of Medicine, Louisiana State University, New Orleans.
Patricia KissingerDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Tulane University · USLouisiana State University · USBaylor College of Medicine · USJackson Memorial Hospital · USUniversity of Mississippi Medical Center · US

Funding

T. vaginalis Recurrence Among HIV+ WomenU19AI061972 · NIAID · LSU HEALTH SCIENCES CENTER · PI MYERS, LEANN · 2004 to 2009
$12.0M
Trichomonas vaginalis repeat infections among HIV negative womenR01AI097080 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KISSINGER, PATRICIA J · 2012 to 2016
$3.7M
NIAID NIH HHS R01 AI097080NIAID NIH HHS U19 260AI061972NIAID NIH HHS U19 AI061972
6 · The paper itself

Abstract

objectiveAmong women who are human immunodeficiency virus positive (HIV+), both prevalent and persistent infections with Trichomonas vaginalis (TV) are common. TV has been shown to increase vaginal shedding of HIV, which may influence HIV sexual and perinatal transmission, making prevention important. In 1 cohort of HIV+ women in Kenya, antiretroviral therapy (ART) use, mostly nevirapine based, was associated with lower cure rates of TV for single-dose therapy. Our goal was to repeat this study in a US-based cohort of HIV+/TV+ women and compare outcomes to those with multidose therapy.

methodsA secondary data analysis was performed on a multicentered cohort of HIV+/TV+ women who were randomized to single-dose (2 grams) or 7-day (500 mg twice daily) multidose metronidazole (MTZ) treatment. Test of cure visit, via culture, occurred 6-12 days after treatment completion. Information was collected on sex partner treatment and sexual exposures. Persistent TV infection rates were compared for women on ART at baseline vs not on ART.

resultsOf the 226 women included, those on ART had more treatment failures than women not on ART (24/146 [16.4%] vs 5/80 [6.3%]; P = .03). When stratified by treatment arm, more treatment failures were seen in the single-dose arm (17/73 [23.3%] vs 3/39 [7.7%]; P = .05) than in the multidose arm (7/73 [9.6%] vs 2/41 [4.8%]; P = .39).

conclusionsART usage was associated with a higher TV persistent infection rate among those receiving the single-dose treatment, but not the multidose, providing more evidence that multidose should be the preferred treatment for HIV+ women.

Indexed as

Antiretroviral Therapy, Highly ActiveAdultAnti-HIV AgentsAntiprotozoal AgentsCD4 Lymphocyte CountCoinfectionFemaleHIV InfectionsHumansMaleRisk FactorsTreatment OutcomeTrichomonas vaginalisTrichomonas VaginitisViral LoadAnti-HIV AgentsAntiprotozoal AgentsantiretroviralHIVmetronidazoleTrichomonas vaginalis

Identifiers

PMID24917661
PMCPMC4200043
OpenAlexW2138171513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.