ArticleAngewandte Chemie (International ed. in English)2014
Iridium-catalyzed enantioselective allylic substitution of unstabilized enolates derived from α,β-unsaturated ketones.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 69 citations in OpenAlex.
- Iridium-Catalyzed Enantioselective Vinylogous and Bisvinylogous Allenylic Substitution.JACS Au · 2024Article
- Expanding the chemical space of enol silyl ethers: catalytic dicarbofunctionalization enabled by iron catalysis.Chemical science · 2023Article
- Catalytic asymmetric defluorinative allylation of silyl enol ethers.Chemical science · 2023Article
- Ir-Catalyzed Chemo-, Regio-, and Enantioselective Allylic Enolization of 6,6-Dimethyl-3-((trimethylsilyl)oxy)cyclohex-2-en-1-one Involving Keto-Enol Isomerization.Molecules (Basel, Switzerland) · 2022Article
- Article
- The Allylic Alkylation of Ketone Enolates.ChemistryOpen · 2020Review
- Brønsted acid and Pd-PHOX dual-catalysed enantioselective addition of activated C-pronucleophiles to internal dienes.Chemical science · 2019Article
- Diastereo- and Enantioselective Access to Stereotriads through a Flexible Coupling of Substituted Aldehydes and Alkenes.Angewandte Chemie (International ed. in English) · 2019Article
- Iridium-Catalyzed Enantioselective Allylic Substitution of Aliphatic Esters with Silyl Ketene Acetals as the Ester Enolates.Angewandte Chemie (International ed. in English) · 2017Article
- Iridium-Catalyzed Regio- and Enantioselective Allylic Substitution of Trisubstituted Allylic Electrophiles.Angewandte Chemie (International ed. in English) · 2016Article
- Iridium-Catalyzed Enantioselective Allylic Substitution of Enol Silanes from Vinylogous Esters and Amides.Journal of the American Chemical Society · 2015Article
- Diastereo- and enantioselective iridium-catalyzed allylation of cyclic ketone enolates: synergetic effect of ligands and barium enolates.Journal of the American Chemical Society · 2014Article
- Iridium-catalyzed regio- and enantioselective allylic substitution of silyl dienolates derived from dioxinones.Angewandte Chemie (International ed. in English) · 2014Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
We report Ir-catalyzed, enantioselective allylic substitution reactions of unstabilized silyl enolates derived from α,β-unsaturated ketones. Asymmetric allylic substitution of a variety of allylic carbonates with silyl enolates gave allylated products in 62-94% yield with 90-98% ee and >20:1 branched-to-linear selectivity. The synthetic utility of this method was illustrated by the short synthesis of an anticancer agent, TEI-9826.
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