ArticleDevelopment (Cambridge, England)2014
Atlas-builder software and the eNeuro atlas: resources for developmental biology and neuroscience.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The cellular basis of locomotor evolution: insights from larval insects.Current opinion in behavioral sciences · 2026Article
- 40 years of homeodomain transcription factors in the Drosophila nervous system.Development (Cambridge, England) · 2024Review
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- Learning Probabilistic Piecewise Rigid Atlases of Model Organisms via Generative Deep Networks.Information processing in medical imaging : proceedings of the ... conference · 2023Article
- A Drosophila model of the neurological symptoms in Mpv17-related diseases.Scientific reports · 2022Article
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- Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in theeLife · 2022Article
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- Tissue clearing and its applications in neuroscience.Nature reviews. Neuroscience · 2020Review
- Review
- A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila.Nature communications · 2019Article
- A gene expression atlas of embryonic neurogenesis inDevelopment (Cambridge, England) · 2019Article
- Neural circuits driving larval locomotion in Drosophila.Neural development · 2018Review
- Whole-organism cellular gene-expression atlas reveals conserved cell types in the ventral nerve cord ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Single neuron transcriptomics identify SRSF/SR protein B52 as a regulator of axon growth and Choline acetyltransferase splicing.Scientific reports · 2016Article
- Functional Genetic Screen to Identify Interneurons Governing Behaviorally Distinct Aspects of Drosophila Larval Motor Programs.G3 (Bethesda, Md.) · 2016Article
- Article
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Authors and funding
11 authors.
Funding
Abstract
A major limitation in understanding embryonic development is the lack of cell type-specific markers. Existing gene expression and marker atlases provide valuable tools, but they typically have one or more limitations: a lack of single-cell resolution; an inability to register multiple expression patterns to determine their precise relationship; an inability to be upgraded by users; an inability to compare novel patterns with the database patterns; and a lack of three-dimensional images. Here, we develop new 'atlas-builder' software that overcomes each of these limitations. A newly generated atlas is three-dimensional, allows the precise registration of an infinite number of cell type-specific markers, is searchable and is open-ended. Our software can be used to create an atlas of any tissue in any organism that contains stereotyped cell positions. We used the software to generate an 'eNeuro' atlas of the Drosophila embryonic CNS containing eight transcription factors that mark the major CNS cell types (motor neurons, glia, neurosecretory cells and interneurons). We found neuronal, but not glial, nuclei occupied stereotyped locations. We added 75 new Gal4 markers to the atlas to identify over 50% of all interneurons in the ventral CNS, and these lines allowed functional access to those interneurons for the first time. We expect the atlas-builder software to benefit a large proportion of the developmental biology community, and the eNeuro atlas to serve as a publicly accessible hub for integrating neuronal attributes - cell lineage, gene expression patterns, axon/dendrite projections, neurotransmitters--and linking them to individual neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.