Evidence map›Paper›PMID 24917305›Full record

ReviewNature reviews. Neuroscience2014

Light as a central modulator of circadian rhythms, sleep and affect.

Tara A LeGates, Diego C Fernandez, Samer Hattar

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 403 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
403citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02653040 nacompletednot on this mapstarted 2015, after this paper: background citation

Light as an Aid for Recovery in Psychiatric Inpatients: A Pragmatic Randomized Controlled Pilot Trial

TypeinterventionalSponsorUniversity of AarhusRan2015 to 2018Enrolled54ConditionsMental IllnessArmsDynamic lighting
NCT03758768 nacompletednot on this mapstarted 2018, after this paper: background citation

The Effects of a Blue Monochromatic Light Intervention on Evening-type Individuals' Sleep and Circadian Rhythms

TypeinterventionalSponsorUniversity of BergenRan2018 to 2018Enrolled34ConditionsCircadian Rhythm Sleep Disorder, Delayed Sleep Phase, SleepArmsBlue light exposure, Full spectrum light exposure
NCT07517484 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects and Mechanisms of Ambient Light Intensity on the Depth of General Anesthesia

TypeinterventionalSponsorPeking University People's HospitalRan2025 to 2026Enrolled66ConditionsLight, Anesthesia, SedationArmseye mask
3 · Its place in the literature

Who cites it

403 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  9. A double-blind, controlled trial of circadian effective light therapy in patients with Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Trial
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  13. Bright light therapy for CPAP-resistant OSA symptoms.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Trial
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  20. Observational

343 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tara A LeGates1] Johns Hopkins University, Department of Biology, Baltimore, Maryland 21218, USA. [2] Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Diego C FernandezJohns Hopkins University, Department of Biology, Baltimore, Maryland 21218, USA.
Samer Hattar1] Johns Hopkins University, Department of Biology, Baltimore, Maryland 21218, USA. [2] Johns Hopkins University, Department of Neuroscience, Baltimore, Maryland 21218, USA.

Funding

CELLULAR AND MOLECULAR BIOLOGYT32GM007231 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 1985 to 2020
$18.4M
Role of mammalian retinal photoreceptors in non-image-forming visual functionsR01GM076430 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ZHAO, HAIQING · 2005 to 2018
$4.8M
Light direct effects on mood and cognitive functionsR21EY024452 · NEI · JOHNS HOPKINS UNIVERSITY · PI HATTAR, SAMER · 2014 to 2015
$430k
NEI NIH HHS R21 EY024452NIGMS NIH HHS R01 GM076430NIGMS NIH HHS T32 GM007231
6 · The paper itself

Abstract

Light has profoundly influenced the evolution of life on earth. As widely appreciated, light enables us to generate images of our environment. However, light - through intrinsically photosensitive retinal ganglion cells (ipRGCs) - also influences behaviours that are essential for our health and quality of life but are independent of image formation. These include the synchronization of the circadian clock to the solar day, tracking of seasonal changes and the regulation of sleep. Irregular light environments lead to problems in circadian rhythms and sleep, which eventually cause mood and learning deficits. Recently, it was found that irregular light can also directly affect mood and learning without producing major disruptions in circadian rhythms and sleep. In this Review, we discuss the indirect and direct influence of light on mood and learning, and provide a model for how light, the circadian clock and sleep interact to influence mood and cognitive functions.

Indexed as

LightAffectAnimalsCircadian RhythmHumansLearningNerve NetRetinaSleepWakefulness

Identifiers

PMID24917305
PMCPMC4254760

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.