ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2014
Peptide formation mechanism on montmorillonite under thermal conditions.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 43 citations in OpenAlex.
- Clay Minerals, Panacea or Parameter in RNA Oligomerization?Journal of molecular evolution · 2026Article
- Prebiotic Roles of Formaldehyde as an Activating Agent and a Building Block in Solid-State Peptide Modification.ACS bio & med chem Au · 2025Article
- Prebiotic Peptide Synthesis: How Did Longest Peptide Appear?Journal of molecular evolution · 2025Review
- Meteorite-common amino acid induces clay exfoliation and abiotic compartment formation.Communications earth & environment · 2025Article
- Prebiotic Synthesis ofJournal of the American Chemical Society · 2023Article
- Selective incorporation of proteinaceous over nonproteinaceous cationic amino acids in model prebiotic oligomerization reactions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Environmental control programs the emergence of distinct functional ensembles from unconstrained chemical reactions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Influence of Mineral Matrices on the Thermal Behavior of Glycine.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2017Article
- Thermal Condensation of Glycine and Alanine on Metal Ferrite Surface: Primitive Peptide Bond Formation Scenario.Life (Basel, Switzerland) · 2017Article
- Formation of Diastereoisomeric Piperazine-2,5-dione from DL-Alanine in the Presence of Olivine and Water.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2017Article
- Abiogenic Syntheses of Lipoamino Acids and Lipopeptides and their Prebiotic Significance.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2015Article
- Formation of oligopeptides in high yield under simple programmable conditions.Nature communications · 2015Article
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3 authors at 1 institution in 1 country.
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Abstract
The oligomerization of amino acids is an essential process in the chemical evolution of proteins, which are precursors to life on Earth. Although some researchers have observed peptide formation on clay mineral surfaces, the mechanism of peptide bond formation on the clay mineral surface has not been clarified. In this study, the thermal behavior of glycine (Gly) adsorbed on montmorillonite was observed during heating experiments conducted at 150 °C for 336 h under dry, wet, and dry-wet conditions to clarify the mechanism. Approximately 13.9 % of the Gly monomers became peptides on montmorillonite under dry conditions, with diketopiperazine (cyclic dimer) being the main product. On the other hand, peptides were not synthesized in the absence of montmorillonite. Results of IR analysis showed that the Gly monomer was mainly adsorbed via hydrogen bonding between the positively charged amino groups and negatively charged surface sites (i.e., Lewis base sites) on the montmorillonite surface, indicating that the Lewis base site acts as a catalyst for peptide formation. In contrast, peptides were not detected on montmorillonite heated under wet conditions, since excess water shifted the equilibrium towards hydrolysis of the peptides. The presence of water is likely to control thermodynamic peptide production, and clay minerals, especially those with electrophilic defect sites, seem to act as a kinetic catalyst for the peptide formation reaction.
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