ArticleBiological trace element research2014
Analysis of human serum and whole blood for mineral content by ICP-MS and ICP-OES: development of a mineralomics method.
Article in Biological trace element research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 159 citations in OpenAlex.
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- Plasma mineral status after a six-month intervention providing one egg per day to young Malawian children: a randomized controlled trial.Scientific reports · 2023Trial
- Plasma elemental responses to red meat ingestion in healthy young males and the effect of cooking method.European journal of nutrition · 2019Trial
- Analysis of Dissolution, Pharmacokinetic, and Bone-Protective Differences Among Calcium Formulations with Different Dosage Forms and Calcium Sources.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Designing a Whole-Cell Biosensor for Detection of Toxic Metals Using Intein Splicing Inhibition ofACS omega · 2026Article
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- Systemic dysregulation of essential and toxic elements and redox homeostasis in gynecologic malignancies.Frontiers in oncology · 2026Article
- Associations between element mixtures and biomarkers of pathophysiologic pathways related to autism spectrum disorder.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2025Article
- Status of Selenium and Other Essential and Toxic Elements in Oregon Grazing Sheep.Animals : an open access journal from MDPI · 2025Article
- Estimation of dietary copper requirements of Coho salmon Oncorhynchus kisutch (Walbaum, 1792), and effects on the growth performance, tissue Cu content, antioxidant capacity and hematological parameters.Scientific reports · 2025Article
- Platelet-Released Growth Factors (PRGFs) Activate NRF2-ARE and Modulate Inflammatory Response in an NRF2-Dependent Manner in Primary Human Keratinocytes.Journal of cosmetic dermatology · 2025Article
- The Role of Energy-Dispersive X-Ray Fluorescence to Predict Mineral Content in Untreated Bovine Plasma.Animals : an open access journal from MDPI · 2025Article
- Insights into the Age-Dependent Variation in Nutrition-Related Trace Elements in Diabetes Blood Using Total Reflection X-Ray Fluorescence.Biological trace element research · 2025Article
- Copper biomarkers and their relationship with parameters of insulin resistance in obese women.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Observational
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- Inductively Coupled Plasma Mass Spectrometry Performance for the Measurement of Key Serum Minerals: A Comparative Study With Standard Quantification Methods.Journal of clinical laboratory analysis · 2025Article
- Blood Concentration of Macro- and Microelements in Women Who Are Overweight/Obesity and Their Associations with Serum Biochemistry.Life (Basel, Switzerland) · 2024Article
- Selenium Biomarkers and Their Relationship to Cardiovascular Risk Parameters in Obese Women.Biological trace element research · 2024Article
- Accumulation of copper and lead in ruminants grazing on a contaminated shooting range in Nordland County, Norway.Environmental science and pollution research international · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Minerals are inorganic compounds that are essential to the support of a variety of biological functions. Understanding the range and variability of the content of these minerals in biological samples can provide insight into the relationships between mineral content and the health of individuals. In particular, abnormal mineral content may serve as an indicator of illness. The development of robust, reliable analytical methods for the determination of the mineral content of biological samples is essential to developing biological models for understanding the relationship between minerals and illnesses. This paper describes a method for the analysis of the mineral content of small volumes of serum and whole blood samples from healthy individuals. Interday and intraday precision for the mineral content of the blood (250 μL) and serum (250 μL) samples was measured for eight essential minerals--sodium (Na), calcium (Ca), magnesium (Mg), potassium (K), iron (Fe), zinc (Zn), copper (Cu), and selenium (Se)--by plasma spectrometric methods and ranged from 0.635 to 10.1% relative standard deviation (RSD) for serum and 0.348-5.98% for whole blood. A comparison of the determined ranges for ten serum samples and six whole blood samples provided good agreement with literature reference ranges. The results demonstrate that the digestion and analysis methods can be used to reliably measure the content of these minerals and potentially of other minerals.
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Registered trials
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