ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2014
How wasting is saving: weight loss at altitude might result from an evolutionary adaptation.
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Helpful to Live Healthier? Intermittent Hypoxic/Ischemic Training Benefits Vascular Homeostasis and Lipid Metabolism with Activating SIRT1 Pathways in Overweight/Obese Individuals.Obesity facts · 2024Trial
- Physiological and Genetic Basis of High-Altitude Indigenous Animals' Adaptation to Hypoxic Environments.Animals : an open access journal from MDPI · 2024Review
- Effects of resistance training on alleviating hypoxia-induced muscle atrophy: Focus on acetylation of FoxO1.Journal of cellular and molecular medicine · 2024Article
- All roads lead to Rome: the plasticity of gut microbiome drives the extensive adaptation of the Yarkand toad-headed agama (Frontiers in microbiology · 2024Article
- Weight Loss and Fat Metabolism during Multi-Day High-Altitude Sojourns: A Hypothesis Based on Adipocyte Signaling.Life (Basel, Switzerland) · 2022Review
- Neuromuscular fatigability at high altitude: Lowlanders with acute and chronic exposure, and native highlanders.Acta physiologica (Oxford, England) · 2022Review
- Effects of acute and sub-acute hypobaric hypoxia on oxidative stress: a field study in the Alps.European journal of applied physiology · 2021Article
- Systems View of Deconditioning During Spaceflight Simulation in the PlanHab Project: The Departure of UrineFrontiers in physiology · 2020Article
- Metabolomic and lipidomic plasma profile changes in human participants ascending to Everest Base Camp.Scientific reports · 2019Article
- Metabolic derangements of skeletal muscle from a murine model of glioma cachexia.Skeletal muscle · 2019Article
- Cholesterol Prevents Hypoxia-Induced Hypoglycemia by Regulation of a Metabolic Ketogenic Shift.Oxidative medicine and cellular longevity · 2019Article
- Amino Acid-Based Metabolic Indexes Identify Patients With Chronic Obstructive Pulmonary Disease And Further Discriminates Patients In Advanced BODE Stages.International journal of chronic obstructive pulmonary disease · 2019Article
- Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics.The Journal of biological chemistry · 2018Article
- Potential Synergies ofJournal of nutrition and metabolism · 2018Review
- Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition.Redox biology · 2017Article
- Mitochondrial function at extreme high altitude.The Journal of physiology · 2016Review
- HIF-1-driven skeletal muscle adaptations to chronic hypoxia: molecular insights into muscle physiology.Cellular and molecular life sciences : CMLS · 2015Review
- A case study evaluation of competitors undertaking an antarctic ultra-endurance event: nutrition, hydration and body composition variables.Extreme physiology & medicine · 2015Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At extreme altitude (>5,000 - 5,500 m), sustained hypoxia threatens human function and survival, and is associated with marked involuntary weight loss (cachexia). This seems to be a coordinated response: appetite and protein synthesis are suppressed, and muscle catabolism promoted. We hypothesise that, rather than simply being pathophysiological dysregulation, this cachexia is protective. Ketone bodies, synthesised during relative starvation, protect tissues such as the brain from reduced oxygen availability by mechanisms including the reduced generation of reactive oxygen species, improved mitochondrial efficiency and activation of the ATP-sensitive potassium (KATP ) channel. Amino acids released from skeletal muscle also protect cells from hypoxia, and may interact synergistically with ketones to offer added protection. We thus propose that weight loss in hypoxia is an adaptive response: the amino acids and ketone bodies made available act not only as metabolic substrates, but as metabolic modulators, protecting cells from the hypoxic challenge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.