Trial reportPsycho-oncology2015
Inflammation and psychosocial factors mediate exercise effects on sleep quality in breast cancer survivors: pilot randomized controlled trial.
Trial report in Psycho-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01147367 (Physical Activity Benefits After Breast Cancer), which is not on this map. Cited by 33 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Physical Activity Benefits After Breast Cancer: Exploring Cytokine Mechanisms
Who cites it
33 citing papers in PubMed, 11 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Effects of exercise interventions on sleep quality in breast cancer survivors: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Efficacy of supervised exercise on sleep of women who survived breast cancer: a systematic review with meta-analysis.Journal of cancer survivorship : research and practice · 2025Pooled it
- Combined Aerobic and Resistance Training Improves Body Composition, Alters Cardiometabolic Risk, and Ameliorates Cancer-Related Indicators in Breast Cancer Patients and Survivors with Overweight/Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of sports science & medicine · 2024Pooled it
- The Use of Wearable Devices in Oncology Patients: A Systematic Review.The oncologist · 2024Pooled it
- Pooled it
- Home-based exercise improves quality of life in breast and prostate cancer survivors: A meta-analysis.PloS one · 2023Pooled it
- Effects of physical activity on sleep problems in breast cancer survivors: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Pooled it
- Effects of Diet and Exercise-Induced Weight Loss on Biomarkers of Inflammation in Breast Cancer Survivors: A Systematic Review and Meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Pooled it
- Different Methods of Physical Training Applied to Women Breast Cancer Survivors: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Interventions for promoting habitual exercise in people living with and beyond cancer.The Cochrane database of systematic reviews · 2018Pooled it
- Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018Pooled it
- Relationship between social support, physical symptoms, and depression in women with breast cancer and pain.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Trial
- Effects of a wearable technology-based physical activity intervention on sleep quality in breast cancer survivors: the ACTIVATE Trial.Journal of cancer survivorship : research and practice · 2021Trial
- The impact of an exercise program on quality of life in older breast cancer survivors undergoing aromatase inhibitor therapy: a randomized controlled trial.Health and quality of life outcomes · 2019Trial
- Investigating dose-response effects of multimodal exercise programs on health-related quality of life in older adults.Clinical interventions in aging · 2019Trial
- Physical Activity and Sleep Quality in Breast Cancer Survivors: A Randomized Trial.Medicine and science in sports and exercise · 2017Trial
- Lifestyle patterns and sleep disturbance among Black breast cancer survivors: results from the Women's Circle of Health Follow-Up Study.The oncologist · 2026Article
- Sleep Disturbance at Cancer Diagnosis and Its Associations With Depressive Symptoms and Systemic Inflammatory Burden.Psycho-oncology · 2026Article
- Article
- Japan's cancer survivorship guidelines for exercise and physical activity.Japanese journal of clinical oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo improve mechanistic understanding, this pilot randomized controlled trial examined mediators of an exercise intervention effects on sleep in breast cancer survivors (BCS).
methodsForty-six postmenopausal BCS (≤Stage II, off primary treatment) were randomized to a 3-month exercise intervention or control group. Intervention included 160 min/week of moderate intensity aerobic walking, twice weekly resistance training (resistance bands), and six discussion groups (to improve adherence). Blinded assessments at baseline and post-intervention included sleep disturbance (PSQI and PROMIS®), objective sleep quality (accelerometer), serum cytokines, accelerometer physical activity, cardiorespiratory fitness, body composition, fatigue, and psychosocial factors. Mediation was tested using Freedman-Schatzkin difference-in-coefficients tests.
resultsWhen compared with control, the intervention group demonstrated a significant increase in PSQI sleep duration (i.e., fewer hours of sleep/night) (d = 0.73, p = .03). Medium to large but non-significant standardized effect sizes were noted for PSQI daytime somnolence (d = -0.63, p = .05) and accelerometer latency (d = -0.49, p = .14). No statistically significant mediators were detected for PSQI sleep duration score or accelerometer latency. Daytime somnolence was mediated by tumor necrosis factor-alpha (mediated 23% of intervention effect, p < .05), interleukin (IL)-6:IL-10 (16%, p < .01), IL-8:IL-10 (26%, p < .01), and fatigue (38%, p < .05). Mediating or enhancing relationships for several of the sleep outcomes were noted for accelerometer physical activity, PROMIS® fatigue, exercise social support, and/or physical activity enjoyment.
conclusionsInflammation and psychosocial factors may mediate or enhance sleep response to our exercise intervention. Further study is warranted to confirm our results and translate our findings into more effective interventions aimed at improving sleep quality in BCS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.