ArticleJournal of neurology2014
Age dependency of safety and outcome of endovascular therapy for acute stroke.
Article in Journal of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Long-term outcome of endovascular thrombectomy in patients with acute ischemic stroke: a systematic review and meta-analysis.Journal of neurology · 2025Pooled it
- A novel nomogram to predict mortality in patients with stroke: a survival analysis based on the MIMIC-III clinical database.BMC medical informatics and decision making · 2022Trial
- Does Antiplatelet Therapy during Bridging Thrombolysis Increase Rates of Intracerebral Hemorrhage in Stroke Patients?PloS one · 2017Trial
- Impact of age on clinical outcomes after endovascular therapy for large ischemic stroke.Journal of neurology · 2026Article
- Machine learning-based scoring model for predicting mortality in ICU-admitted ischemic stroke patients with moderate to severe consciousness disorders.Frontiers in neurology · 2025Article
- Development and validation of a nomogram for predicting 28-day mortality in patients with ischemic stroke.PloS one · 2024Article
- [An interpretable machine learning-based prediction model for risk of death for patients with ischemic stroke in intensive care unit].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- A study on endovascular treatment alone and bridging treatment for acute ischemic stroke.European journal of medical research · 2023Article
- Impact of pre-stroke dependency on outcome after endovascular therapy in acute ischemic stroke.Journal of neurology · 2021Article
- A NADE nomogram to predict the probability of 6-month unfavorable outcome in Chinese patients with ischemic stroke.BMC neurology · 2019Article
- Association of anemia and hemoglobin decrease during acute stroke treatment with infarct growth and clinical outcome.PloS one · 2018Article
- Article
- Focal T2 and FLAIR hyperintensities within the infarcted area: A suitable marker for patient selection for treatment?PloS one · 2017Article
- Endovascular mechanical recanalization of acute ischaemic stroke in octogenarians.European radiology · 2016Article
- TICI and Age: What's the Score?AJNR. American journal of neuroradiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elderly patients generally experience less favorable outcomes and higher mortality after acute stroke than younger patients. The aim of this study was to analyze the influence of age on outcome and safety after endovascular therapy in a large cohort of patients aged between 20 and 90 years. We prospectively acquired data of 1,000 stroke patients treated with endovascular therapy at a single center. Logistic regression analysis was performed to determine predictors of outcome and linear regression analysis to evaluate the association of age and outcome after 3 months. Younger age was an independent predictor of favorable outcome (OR 0.954, p < 0.001) and survival (OR 0.947, p < 0.001) in multivariate regression analysis. There was a linear relationship between age and outcome. Ever increase in 26 years of age was associated with an increase in the modified Rankin Scale of 1 point (p < 0.001). However, increasing age was not a risk factor for symptomatic (p = 0.086) or asymptomatic (p = 0.674) intracerebral hemorrhage and did not influence recanalization success (p = 0.674). Advancing age was associated with a decline of favorable outcomes and survival after endovascular therapy. This decline was linear from age 20 to 90 years, but was not related to lower recanalization rates or higher bleeding risk in the elderly. The efficacy of endovascular stroke therapy seems to be preserved also in the elderly and other factors than efficacy of endovascular therapy such as decreased plasticity are likely to explain the worse outcome with advancing age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.