Evidence map›Paper›PMID 24916793›Full record

ArticleJournal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)2015

Variance components of short-term biomarkers of manganese exposure in an inception cohort of welding trainees.

Marissa G Baker, Christopher D Simpson, Lianne Sheppard, Bert Stover, Jackie Morton, John Cocker, Noah Seixas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  8. Consequences of Disturbing Manganese Homeostasis.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Using exposure windows to explore an elusive biomarker: blood manganese.International archives of occupational and environmental health · 2016
    Article
  19. Article
  20. Manganese Toxicity Upon Overexposure: a Decade in Review.Current environmental health reports · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Marissa G BakerDepartment of Environmental and Occupational Health Sciences, University of Washington, 1959 Pacific St., Seattle, WA 98195, USA. Electronic address: bakermg@uw.edu.
Christopher D SimpsonDepartment of Environmental and Occupational Health Sciences, University of Washington, 1959 Pacific St., Seattle, WA 98195, USA.
Lianne SheppardDepartment of Environmental and Occupational Health Sciences, University of Washington, 1959 Pacific St., Seattle, WA 98195, USA; Department of Biostatistics, University of Washington, 1705 NE Pacific St., Seattle, WA 98195, USA.
Bert StoverDepartment of Environmental and Occupational Health Sciences, University of Washington, 1959 Pacific St., Seattle, WA 98195, USA; Department of Health Services, University of Washington, 1959 Pacific St., Seattle, WA 98195, USA.
Jackie MortonHealth and Safety Laboratory, Harpur Hill, Buxton, Derbyshire SK17 9JN, UK.
John CockerHealth and Safety Laboratory, Harpur Hill, Buxton, Derbyshire SK17 9JN, UK.
Noah SeixasDepartment of Environmental and Occupational Health Sciences, University of Washington, 1959 Pacific St., Seattle, WA 98195, USA.
University of Washington · USHealth & Safety Laboratory · GB

Funding

Characterization of manganese exposure biomarkers among welder apprenticesR01ES017809 · NIEHS · UNIVERSITY OF WASHINGTON · PI SEIXAS, NOAH S · 2010 to 2012
$1.5M
NIEHS NIH HHS R01 ES017809NIEHS NIH HHS R01ES017809
6 · The paper itself

Abstract

Various biomarkers of exposure have been explored as a way to quantitatively estimate an internal dose of manganese (Mn) exposure, but given the tight regulation of Mn in the body, inter-individual variability in baseline Mn levels, and variability in timing between exposure and uptake into various biological tissues, identification of a valuable and useful biomarker for Mn exposure has been elusive. Thus, a mixed model estimating variance components using restricted maximum likelihood was used to assess the within- and between-subject variance components in whole blood, plasma, and urine (MnB, MnP, and MnU, respectively) in a group of nine newly-exposed apprentice welders, on whom baseline and subsequent longitudinal samples were taken over a three month period. In MnB, the majority of variance was found to be between subjects (94%), while in MnP and MnU the majority of variance was found to be within subjects (79% and 99%, respectively), even when controlling for timing of sample. While blood seemed to exhibit a homeostatic control of Mn, plasma and urine, with the majority of the variance within subjects, did not. Results presented here demonstrate the importance of repeat measure or longitudinal study designs when assessing biomarkers of Mn, and the spurious associations that could result from cross-sectional analyses.

Indexed as

WeldingAir Pollutants, OccupationalBiomarkersCohort StudiesDemographyHumansLimit of DetectionManganeseOccupational ExposureTime FactorsYoung AdultAir Pollutants, OccupationalBiomarkersManganeseBiomarkers of exposureManganeseVariabilityWelders

Identifiers

PMID24916793
PMCPMC4241381
OpenAlexW2086993467

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.