ArticleDigestive diseases and sciences2014
Experience with OxyELITE pro and acute liver injury in active duty service members.
Article in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Hepatotoxicity due to herbal dietary supplements: Past, present and the future.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022Review
- Severe liver injury due to herbal and dietary supplements and the role of liver transplantation.World journal of gastroenterology · 2019Review
- Severe Acute Hepatitis Attributed to the Herbal and Dietary Supplement OxyELITE Pro.Clinical liver disease · 2019Review
- Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Multistate Outbreak of Salmonella Virchow Infections Linked to a Powdered Meal Replacement Product-United States, 2015-2016.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Recent Advances in the Histopathology of Drug-Induced Liver Injury.Surgical pathology clinics · 2018Review
- Surveillance of the armed forces as a sentinel system for detecting adverse effects of dietary supplements in the general population.Public health nutrition · 2018Article
- Adverse Effects of Nutraceuticals and Dietary Supplements.Annual review of pharmacology and toxicology · 2018Review
- Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2017Article
- Hepatotoxicity associated with weight loss or sports dietary supplements, including OxyELITE Pro™ - United States, 2013.Drug testing and analysis · 2017Article
- Liver injury from herbal and dietary supplements.Hepatology (Baltimore, Md.) · 2017Review
- Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series.Digestive diseases and sciences · 2016Observational
- Review
- Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics.International journal of molecular sciences · 2016Review
- Scientific and Regulatory Perspectives in Herbal and Dietary Supplement Associated Hepatotoxicity in the United States.International journal of molecular sciences · 2016Review
- Effects of controlled doses of Oxyelite Pro on physical performance in rats.Nutrition & metabolism · 2016Article
- Liver Injury from Herbal, Dietary, and Weight Loss Supplements: a Review.Journal of clinical and translational hepatology · 2015Review
- Abuse liability of the dietary supplement dimethylamylamine.Drug and alcohol dependence · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1,3-dimethylamylamine (DMAA) is a common additive in sport supplements that was banned by the FDA in 2013. Specifically, this additive received much publication for its role in causing adverse cardiovascular events, particularly sudden cardiac death. However, it has been our experience that products containing this additive may also lead to acute liver injury and liver failure. We present a series of seven cases encountered by a military treatment facility in Southern California which involved the use of OxyELITE Pro, a sport supplement containing DMAA, that all resulted in acute liver injury with two cases requiring transplant for acute liver failure. To our knowledge, this is the first case series reported involving OxyELITE Pro or other DMAA-containing supplements with a specific focus on acute liver injury. This review is limited by the paucity of clinical studies and trials based on OxyElite Pro and its effect on the liver. The presented cases are notably observation, and no standardized diagnostic or treatment protocol was utilized. This series is important to the general population as a whole due to the prevalence of sport supplement use, and is particularly important for practitioners who work with the military or athletic populations due to the high use in these demographics. These cases are followed by a brief discussion regarding DMAA.
Indexed as
Identifiers
24916713What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.