ArticleJournal of molecular evolution2014
Genetic code evolution started with the incorporation of glycine, followed by other small hydrophilic amino acids.
Article in Journal of molecular evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The Evolution of the First Code.Genes · 2026Review
- Chemical Evolution of Life on Earth.Genes · 2025Review
- The 3 31 Nucleotide Minihelix tRNA Evolution Theorem and the Origin of Life.Life (Basel, Switzerland) · 2023Review
- A self-sustaining serpentinization mega-engine feeds the fougerite nanoengines implicated in the emergence of guided metabolism.Frontiers in microbiology · 2023Article
- On the Evolutionary History of the Twenty Encoded Amino Acids.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Review
- Evolution of the genetic code.Transcription · 2021Review
- Evolution of the genetic code; Evidence from serine codon use disparity inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Universal Codons with Enrichment from GC to AU Nucleotide Composition Reveal a Chronological Assignment from Early to Late Along with LUCA Formation.Life (Basel, Switzerland) · 2020Article
- Evolution of Life on Earth: tRNA, Aminoacyl-tRNA Synthetases and the Genetic Code.Life (Basel, Switzerland) · 2020Review
- Adaptive Properties of the Genetically Encoded Amino Acid Alphabet Are Inherited from Its Subsets.Scientific reports · 2019Article
- A tRNA- and Anticodon-Centric View of the Evolution of Aminoacyl-tRNA Synthetases, tRNAomes, and the Genetic Code.Life (Basel, Switzerland) · 2019Review
- Ribosome Structure, Function, and Early Evolution.International journal of molecular sciences · 2018Review
- Phenotypic Graphs and Evolution Unfold the Standard Genetic Code as the Optimal.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2018Article
- Rooted tRNAomes and evolution of the genetic code.Transcription · 2018Article
- On the Uniqueness of the Standard Genetic Code.Life (Basel, Switzerland) · 2017Article
- Clues to tRNA Evolution from the Distribution of Class II tRNAs and Serine Codons in the Genetic Code.Life (Basel, Switzerland) · 2016Article
- Origins and Early Evolution of the tRNA Molecule.Life (Basel, Switzerland) · 2015Review
- Beyond the Frozen Accident: Glycine Assignment in the Genetic Code.Journal of molecular evolution · 2015Article
- Proline might have been the first amino acid in the primitive genetic code.Journal of molecular evolution · 2014Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We propose that glycine was the first amino acid to be incorporated into the genetic code, followed by serine, aspartic and/or glutamic acid-small hydrophilic amino acids that all have codons in the bottom right-hand corner of the standard genetic code table. Because primordial ribosomal synthesis is presumed to have been rudimentary, this stage would have been characterized by the synthesis of short, water-soluble peptides, the first of which would have comprised polyglycine. Evolution of the code is proposed to have occurred by the duplication and mutation of tRNA sequences, which produced a radiation of codon assignment outwards from the bottom right-hand corner. As a result of this expansion, we propose a trend from small hydrophilic to hydrophobic amino acids, with selection for longer polypeptides requiring a hydrophobic core for folding and stability driving the incorporation of hydrophobic amino acids into the code.
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