ArticleHuman brain mapping2014
Processing of nociceptive input from posterior to anterior insula in humans.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
85 citing papers in PubMed, 3 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- The efficacy and mechanisms of low-intensity transcranial ultrasound stimulation on pain: a systematic review of human and animal studies.The journal of headache and pain · 2025Pooled it
- Dysregulated anterior insula reactivity as robust functional biomarker for chronic pain-Meta-analytic evidence from neuroimaging studies.Human brain mapping · 2022Pooled it
- A meta-analysis of neuroimaging studies on pain empathy: investigating the role of visual information and observers' perspective.Social cognitive and affective neuroscience · 2019Pooled it
- Neurofeedback modulation of insula activity via MEG-based brain-machine interface: a double-blind randomized controlled crossover trial.Communications biology · 2025Trial
- Longitudinal neurofunctional changes in medication overuse headache patients after mindfulness practice in a randomized controlled trial (the MIND-CM study).The journal of headache and pain · 2024Trial
- Novelty seeking is related to individual risk preference and brain activation associated with risk prediction during decision making.Scientific reports · 2015Trial
- Pyramidal cell types and circuit organization of the mouse insular cortex reveal functional specializations.Nature neuroscience · 2026Article
- Excitatory paraventricular thalamus-posterior insular cortex circuit mediates pain-anxiety comorbidity in diabetic neuropathy.Translational psychiatry · 2026Article
- Modulation of Posterior Insula Selectively Enhances Nociceptive Sensory Gating in Humans.medRxiv : the preprint server for health sciences · 2026Article
- Stable insular spectral patterns underlie dynamic pain encoding in chronic neuropathic pain.Brain communications · 2026Article
- Objective monitoring of acute pain and nociception in anaesthesia and intensive care: evidence and applications.Anaesthesiology intensive therapy · 2025Review
- Article
- Genetic underpinnings and causal effects of brain structure and function on chronic pain intensity.Nature communications · 2025Article
- Neuronal architecture of the mouse insular cortex underlying its diverse functions.bioRxiv : the preprint server for biology · 2025Article
- Decreases in Hormone Levels Modulate Neurovascular Coupling but Not Reduced Insular Functional Connectivity in Menstrual-Related Migraine.Human brain mapping · 2025Article
- Vestibular Versus Cochlear Stimulation on the Relief of Phantom Pain After Traumatic Finger Amputation.Biomedicines · 2025Article
- Insula under the influence: Alcohol-induced changes in resting state functional connectivity.Alcohol, clinical & experimental research · 2025Article
- Nature exposure induces analgesic effects by acting on nociception-related neural processing.Nature communications · 2025Article
- MRI-based neuroimaging alterations in immune-related skin diseases: a comprehensive review.Archives of dermatological research · 2025Review
- Investigating brain dysfunction in neuropathic pain with MRI.Brain communications · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous brain imaging studies have shown robust activations in the insula during nociceptive stimulation. Most activations involve the posterior insular cortex but they can cover all insular gyri in some fMRI studies. However, little is known about the timing of activations across the different insular sub-regions. We report on the distribution of intracerebrally recorded nociceptive laser evoked potentials (LEPs) acquired from the full extent of the insula in 44 epileptic patients. Our study shows that both posterior and anterior subdivisions of the insular cortex respond to a nociceptive heat stimulus within a 200-400 ms latency range. This nociceptive cortical potential occurs firstly, and is larger, in the posterior granular insular cortex. The presence of phase reversals in LEP components in both posterior and anterior insular regions suggests activation of distinct, presumably functionally separate, sources in the posterior and anterior parts of the insula. Our results suggest that nociceptive input is first processed in the posterior insula, where it is known to be coded in terms of intensity and anatomical location, and then conveyed to the anterior insula, where the emotional reaction to pain is elaborated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.