Evidence map›Paper›PMID 24916515›Full record

ArticleJournal of clinical monitoring and computing2015

Repeated early hemofiltration filters clotting and heparin-induced thrombocytopenia in ICU.

Sébastien Perbet, Thomas Godet, Aurélien Lebreton, Anne-Françoise Sapin, Jean-Michel Constantin

Abstract readCase Reports
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In one paragraph

Article in Journal of clinical monitoring and computing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. 4Ts scoring with hemofiltration or hemodialysis clotting.Journal of clinical monitoring and computing · 2015
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sébastien PerbetCHU Clermont-Ferrand, General Intensive Care Unit, University Hospital Estaing, Clermont-Ferrand, France, sperbet@chu-clermontferrand.fr.
Thomas Godet
Aurélien Lebreton
Anne-Françoise Sapin
Jean-Michel Constantin

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repeated early hemofiltration filter clotting are real thrombotic events. Diagnosis of heparin-induced thrombocytopenia (HIT) in this setting in ICU remains difficult. We describe two cases of repeated early hemofiltration filters clotting in ICU and to evaluate their impact on the probability test 4T's score and diagnosis of HIT. Two patients undergoing at least three repeated early hemofiltration clotting filters in <6 h revealing HIT in ICU had a low probability score for HIT. Despite a 4T's score of three for the two patients and persistent early hemofiltration clotting filters, functional tests for HIT antibodies (heparin induced platelet activation assay and serotonin release assay) were positive, permitting the diagnosis of HIT in both patients. We suggest that the occurrence of repeated, rapid (within 6 h) hemofiltration filter clotting should score as two points for "Thrombosis" in the 4T's scoring system, thereby increasing the pretest probability for HIT in this clinical situation.

Indexed as

Aged, 80 and overBlood CoagulationCritical CareHemodynamicsHemofiltrationHeparinHumansImmunoglobulin GIntensive Care UnitsMaleMethicillin-Resistant Staphylococcus aureusPlatelet ActivationPlatelet CountRecurrenceSerotoninSeverity of Illness IndexHeparinImmunoglobulin GSerotonin

Identifiers

PMID24916515

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.