ReviewMetabolic brain disease2014
Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.
Review in Metabolic brain disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Metabolomics study of the effects of zinc sulfate in minimal hepatic encephalopathy.Scientific reports · 2026Article
- Crossed cerebellar diaschisis in a COVID-19 patient with hemiconvulsion-hemiplegia syndrome: a case report and literature review.Italian journal of pediatrics · 2026Review
- Blood-brain barrier dysfunction in hepatic encephalopathy: pathophysiology, diagnostic assessment and therapeutic perspectives.Metabolic brain disease · 2025Review
- Hepatic encephalopathy as a result of ammonia-induced increase in GABAergic tone with secondary reduced brain energy metabolism.Metabolic brain disease · 2024Review
- Evaluation of G3BP1 in the prognosis of acute and acute-on-chronic liver failure after the treatment of artificial liver support system.World journal of hepatology · 2024Article
- The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study.PloS one · 2023Article
- Regulation of mild cognitive impairment associated with liver disease by humoral factors derived from the gastrointestinal tract and MRI research progress: a literature review.Frontiers in neuroscience · 2023Review
- Bile duct ligation differently regulates protein expressions of organic cation transporters in intestine, liver and kidney of rats through activation of farnesoid X receptor by cholate and bilirubin.Acta pharmaceutica Sinica. B · 2023Article
- Cerebrospinal fluid lactate levels along the Alzheimer's disease continuum and associations with blood-brain barrier integrity, age, cognition, and biomarkers.Alzheimer's research & therapy · 2022Article
- Risk Factor Analysis of Hepatic Encephalopathy and the Establishment of Diagnostic Model.BioMed research international · 2022Article
- The neurogliovascular unit in hepatic encephalopathy.JHEP reports : innovation in hepatology · 2021Review
- The Direct Contribution of Astrocytes and Microglia to the Pathogenesis of Hepatic Encephalopathy.Journal of clinical and translational hepatology · 2019Review
- Metabolomic Analysis Identifies Lactate as an Important Pathogenic Factor in Diabetes-associated Cognitive Decline Rats.Molecular & cellular proteomics : MCP · 2018Article
- Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease.Journal of clinical and experimental hepatology · 2018Review
- Cerebral Blood Flow and Metabolism in Hepatic Encephalopathy-A Meta-Analysis.Journal of clinical and experimental hepatology · 2018Review
- Disruption of Intracellular ATP Generation and Tight Junction Protein Expression during the Course of Brain Edema Induced by Subacute Poisoning of 1,2-Dichloroethane.Frontiers in neuroscience · 2018Article
- What we know: the inflammatory basis of hepatic encephalopathy.Metabolic brain disease · 2016Review
- Magnetic Resonance Spectroscopy for Evaluating Portal-Systemic Encephalopathy in Patients with Chronic Hepatic Schistosomiasis Japonicum.PLoS neglected tropical diseases · 2016Article
- Lactate as a Metabolite and a Regulator in the Central Nervous System.International journal of molecular sciences · 2016Review
- Covert hepatic encephalopathy: elevated total glutathione and absence of brain water content changes.Metabolic brain disease · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation, but also in the brain. Traditionally, increased cerebral lactate is considered a marker of energy failure/impairment however alterations in lactate homeostasis may also lead to a rise in brain lactate and result in neuronal dysfunction. The latter may involve the development of brain edema. This review will target the significance of increased cerebral lactate in the pathogenesis of HE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.