Evidence map›Paper›PMID 24916389›Full record

ArticleJournal of biological rhythms2014

Effects of TWIN-OF-EYELESS on Clock Gene Expression and Central-Pacemaker Neuron Development in Drosophila.

Nicholas R J Glossop, Jennet O Gummadova, Indrayani Ghangrekar, Paul E Hardin, Graham A Coutts

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological rhythms, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nicholas R J GlossopFaculty of Life Sciences, University of Manchester, Manchester, UK Nicholas.Glossop@manchester.ac.uk.
Jennet O GummadovaFaculty of Life Sciences, University of Manchester, Manchester, UK.
Indrayani GhangrekarFaculty of Life Sciences, University of Manchester, Manchester, UK Cancer Research UK, London, UK.
Paul E HardinCancer Research UK, London, UK.
Graham A CouttsFaculty of Life Sciences, University of Manchester, Manchester, UK.
University of Manchester · GBCancer Research UK Technology · GB

Funding

Circadian Regulatory Circuits in DrosophilaR01NS051280 · NINDS · UNIVERSITY OF HOUSTON · PI HARDIN, PAUL E · 2005 to 2008
$1.2M
Biotechnology and Biological Sciences Research Council BB/D016339/1NINDS NIH HHS R01 NS051280Wellcome Trust
6 · The paper itself

Abstract

Circadian oscillators are autonomous molecular rhythms that reside in cells to align whole-organism physiology and behavior to the 24-h day. In flies, as in mammals, the oscillator operates in cells that coexpress CLOCK (CLK) and CYCLE (CYC). Recent work in Drosophila has shown that CLK is unique in its ability to generate heterologous oscillators, indicating that Clk gene expression defines the circadian cell fate. Here, using standard in vitro and in vivo techniques, we show that TWIN-OF-EYELESS (TOY; dPax6) regulates Clk expression in small ventrolateral neurons (s-LN

Indexed as

central pacemakercircadian oscillatorDrosophila clocktwin-of-eyeless

Identifiers

PMID24916389
PMCPMC4262727
OpenAlexW2139323169

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.