Evidence map›Paper›PMID 24916274›Full record

ReviewDrugs in R&D2014

A practical approach to the treatment of low-risk childhood fever.

Dipak Kanabar

3 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Drugs in R&D, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02593721 phase2 / phase3completednot on this mapstarted 2015, after this paper: background citation

Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain

TypeinterventionalSponsorUniversidad Europea de MadridRan2015 to 2015Enrolled50ConditionsCervicobrachial NeuralgiaArmsMedian Nerve Neural Mobilization, Ibuprofen
NCT02595294 nacompletednot on this mapstarted 2015, after this paper: background citation

Hypoalgesic Effect of Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group

TypeinterventionalSponsorUniversidad Europea de MadridRan2015 to 2015Enrolled52ConditionsCervicobrachial NeuralgiaArmsCervical Lateral Glide neural mobilization
NCT02596815 nacompletednot on this mapstarted 2015, after this paper: background citation

Hypoalgesic Effect of Median Nerve Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group

TypeinterventionalSponsorUniversidad Europea de MadridRan2015 to 2015Enrolled51ConditionsCervicobrachial NeuralgiaArmsMedian Nerve Neural Mobilization, Goniometer
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Article
  3. Development of an observer-reported outcome measure to capture the signs and impact of fever distress symptoms in infants and young children.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Review
  4. Article
  5. Article
  6. Understanding Discomfort in Order to Appropriately Treat Fever.International journal of environmental research and public health · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Dipak KanabarEvelina London Children's Hospital, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK, dkanabar@doctors.org.uk.
Boston Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fever is a common symptom of childhood infections that in itself does not require treatment. The UK's National Institute for Health and Care Excellence (NICE) advises home-based antipyretic treatment for low-risk feverish children only if the child appears distressed. The recommended antipyretics are ibuprofen or paracetamol (acetaminophen). They are equally recommended for the distressed, feverish child; therefore, healthcare professionals, parents and caregivers need to decide which of these agents to administer if the child is distressed. This narrative literature review examines recent data on ibuprofen and paracetamol in feverish children to determine any clinically relevant differences between these agents. The data suggest that these agents have similar safety profiles in this setting and in the absence of underlying health issues, ibuprofen seems to be more effective than paracetamol at reducing NICE's treatment criterion, 'distress' (as assessed by discomfort levels, symptom relief, and general behavior).

Indexed as

AcetaminophenChildFeverHumansIbuprofenAcetaminophenIbuprofen

Identifiers

PMID24916274
PMCPMC4070461
OpenAlexW2039202477

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.