ArticleAngewandte Chemie (International ed. in English)2014
Chaotropic-anion-induced supramolecular self-assembly of ionic polymeric micelles.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A Multi-Threshold Micelle Improves Tumor Accumulation and STING Immunotherapy.Journal of the American Chemical Society · 2025Article
- Hofmeister Effects Shine in Nanoscience.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Sequential acid/reduction response of triblock copolymeric nanomicelles to release camptothecin and toll-like receptor 7/8 agonist for orchestrated chemoimmunotherapy.Journal of nanobiotechnology · 2022Article
- Non-Globular Organic Ionic Plastic Crystal Containing a Crown-Ether Moiety - Tuning Its Behaviour Using Sodium Salts.Chemphyschem : a European journal of chemical physics and physical chemistry · 2022Article
- Responsive Multivesicular Polymeric Nanovaccines that Codeliver STING Agonists and Neoantigens for Combination Tumor Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- A transistor-like pH-sensitive nanodetergent for selective cancer therapy.Nature nanotechnology · 2022Article
- Article
- Recent Development of pH-Responsive Polymers for Cancer Nanomedicine.Molecules (Basel, Switzerland) · 2018Review
- Cooperativity Principles in Self-Assembled Nanomedicine.Chemical reviews · 2018Review
- Ion-Hydrocarbon and/or Ion-Ion Interactions: Direct and Reverse Hofmeister Effects in a Synthetic Host.Journal of the American Chemical Society · 2018Article
- Ion specific effects on the immobilisation of charged gold nanoparticles on metal surfaces.RSC advances · 2018Article
- Molecular basis of cooperativity in pH-triggered supramolecular self-assembly.Nature communications · 2016Article
- Non-covalent interactions in controlling pH-responsive behaviors of self-assembled nanosystems.Polymer chemistry · 2016Article
- A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles.Nature communications · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Traditional micelle self-assembly is driven by the association of hydrophobic segments of amphiphilic molecules forming distinctive core-shell nanostructures in water. Here we report a surprising chaotropic-anion-induced micellization of cationic ammonium-containing block copolymers. The resulting micelle nanoparticle consists of a large number of ion pairs (≈60,000) in each hydrophobic core. Unlike chaotropic anions (e.g. ClO4(-)), kosmotropic anions (e.g. SO4(2-)) were not able to induce micelle formation. A positive cooperativity was observed during micellization, for which only a three-fold increase in ClO4(-) concentration was necessary for micelle formation, similar to our previously reported ultra-pH-responsive behavior. This unique ion-pair-containing micelle provides a useful model system to study the complex interplay of noncovalent interactions (e.g. electrostatic, van der Waals, and hydrophobic forces) during micelle self-assembly.
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Registered trials
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