ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2014
Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
99 citing papers in PubMed, 2 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- Reproducibility of liver iron concentration measured by R2* method based on 1.5-T MRI: a meta-analysis.European radiology · 2025Pooled it
- Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver.Hepatology international · 2023Guideline
- A randomized controlled trial evaluating the effects of amlodipine on myocardial iron deposition in pediatric patients with thalassemia major.Drug design, development and therapy · 2019Trial
- Liver iron concentration measurements by MRI in chronically transfused children with sickle cell anemia: baseline results from the TWiTCH trial.American journal of hematology · 2015Trial
- Article
- Comparison of hepatic iron quantification by MRI between 1.5 and 3 T, using different methods and conversion formulas.European radiology · 2026Article
- Generalized U-Net for automatic liver segmentation and R2* estimation for assessment of iron overload using MRI.BMC medical imaging · 2026Article
- Revisiting Congenital Atransferrinemia: A Rare but Treatable Cause of Pediatric Heart Failure.Cardiovascular & hematological disorders drug targets · 2026Review
- Liver Tissue Mapping in Transfusion-Dependent β-Thalassemia: Reproducibility and Clinical Insights from Multiparametric MRI.Diagnostics (Basel, Switzerland) · 2025Article
- Discrete truncation method for measuring the cardiac t2* values in patients with thalassemia.Annals of medicine · 2025Article
- Liver iron susceptometry is different in patients with transfusion dependent thalassemia and sickle cell disease compared with hemochromatosis.Biochemistry and biophysics reports · 2025Article
- Validation of R2* magnetic resonance imaging for quantifying secondary iron overload in pediatric patients.Diagnostic and interventional radiology (Ankara, Turkey) · 2025Article
- Simultaneous Multiparameter Mapping of the Liver in a Single Breath-Hold or Respiratory-Triggered Acquisition Using Multi-Inversion Spin and Gradient Echo MRI.Journal of magnetic resonance imaging : JMRI · 2025Article
- Assessment of Cardiac, Hepatic and Pancreatic Iron Overload in Transfusion Dependent Thalassemia Patients Using T2* Magnetic Resonance Imaging.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- Noninvasive Assessment of Liver Fibrosis in Patients With Iron Overload.Ultrasound in medicine & biology · 2025Article
- State-of-the-Art Quantification of Liver Iron With MRI-Vendor Implementation and Available Tools.Journal of magnetic resonance imaging : JMRI · 2025Review
- Iron Chelation Therapy.Advances in experimental medicine and biology · 2025Review
- Iron overload in paediatric oncology: the role of radiology in diagnosing and monitoring secondary haemochromatosis.Polish journal of radiology · 2025Review
- Practical approach to quantitative liver and pancreas MRI in children.Pediatric radiology · 2025Review
- Quantification of liver iron overload among pediatric patients with magnetic resonance imaging: current state of the art.Polish journal of radiology · 2025Review
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThere is a need to standardise non-invasive measurements of liver iron concentrations (LIC) so clear inferences can be drawn about body iron levels that are associated with hepatic and extra-hepatic complications of iron overload. Since the first demonstration of an inverse relationship between biopsy LIC and liver magnetic resonance (MR) using a proof-of-concept T2* sequence, MR technology has advanced dramatically with a shorter minimum echo-time, closer inter-echo spacing and constant repetition time. These important advances allow more accurate calculation of liver T2* especially in patients with high LIC.
methodsHere, we used an optimised liver T2* sequence calibrated against 50 liver biopsy samples on 25 patients with transfusional haemosiderosis using ordinary least squares linear regression, and assessed the method reproducibility in 96 scans over an LIC range up to 42 mg/g dry weight (dw) using Bland-Altman plots. Using mixed model linear regression we compared the new T2*-LIC with R2-LIC (Ferriscan) on 92 scans in 54 patients with transfusional haemosiderosis and examined method agreement using Bland-Altman approach.
resultsStrong linear correlation between ln(T2*) and ln(LIC) led to the calibration equation LIC = 31.94(T2*)-1.014. This yielded LIC values approximately 2.2 times higher than the proof-of-concept T2* method. Comparing this new T2*-LIC with the R2-LIC (Ferriscan) technique in 92 scans, we observed a close relationship between the two methods for values up to 10 mg/g dw, however the method agreement was poor.
conclusionsNew calibration of T2* against liver biopsy estimates LIC in a reproducible way, correcting the proof-of-concept calibration by 2.2 times. Due to poor agreement, both methods should be used separately to diagnose or rule out liver iron overload in patients with increased ferritin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.