Evidence map›Paper›PMID 24915980›Full record

SynthesisAnnals of the rheumatic diseases2015

Imaging modalities for the classification of gout: systematic literature review and meta-analysis.

Alexis Ogdie, William J Taylor, Mark Weatherall, Jaap Fransen, Tim L Jansen, Tuhina Neogi, H Ralph Schumacher, Nicola Dalbeth

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of the rheumatic diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05698680 (Pragmatic, Randomized, Multicenter, Double-blind, Controlled, Clinical Trial of Prednisolone Versus Colchicine for Acute Gout in Primary Care), which is not on this map. Cited by 76 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05698680 phase4terminatednot on this mapstarted 2023, after this paper: background citation

Pragmatic, Randomized, Multicenter, Double-blind, Controlled, Clinical Trial of Prednisolone Versus Colchicine for Acute Gout in Primary Care

TypeinterventionalSponsorUniversity Medicine GreifswaldRan2023 to 2026Enrolled186ConditionsAcute GoutArmsPrednisolone 30 mg Tablet, Colchicine 0.5 mg Oral Tablet
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Guideline
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  10. Review
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  12. Imaging of gout: an atlas.Rheumatology advances in practice · 2025
    Review
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexis OgdieDivision of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
William J TaylorDepartment of Medicine, University of Otago, Wellington, New Zealand.
Mark WeatherallDepartment of Medicine, University of Otago, Wellington, New Zealand.
Jaap FransenDepartment of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Tim L JansenDepartment of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Tuhina NeogiSections of Epidemiology and Rheumatology, Boston University School of Medicine, Boston, Massachusetts, USA.
H Ralph SchumacherDivision of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nicola DalbethDepartment of Medicine, University of Auckland, Auckland, New Zealand.

Funding

Identification of Early Psoriatic ArthritisK23AR063764 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI OGDIE, ALEXIS R. · 2013 to 2017
$751k
NIAMS NIH HHS K23 AR063764
6 · The paper itself

Abstract

backgroundAlthough there has been major progress in gout imaging, no gout classification criteria currently include advanced imaging techniques.

objectiveTo examine the usefulness of imaging modalities in the classification of gout when compared to monosodium urate (MSU) crystal confirmation as the gold standard, in order to inform development of new gout classification criteria.

methodsWe systematically reviewed the published literature concerning the diagnostic performance of plain film radiography, MRI, ultrasound (US), conventional CT and dual energy CT (DECT). Only studies with MSU crystal confirmation as the gold standard were included. When more than one study examined the same imaging feature, the data were pooled and summary test characteristics were calculated.

results11 studies (9 manuscripts and 2 meeting abstracts) satisfied the inclusion criteria. All were set in secondary care, with mean gout disease duration of at least 7 years. Three features were examined in more than one study: the double contour sign (DCS) on US, tophus on US, and MSU crystal deposition on DECT. The pooled (95% CI) sensitivity and specificity of US DCS were 0.83 (0.72 to 0.91) and 0.76 (0.68 to 0.83), respectively; of US tophus, were 0.65 (0.34 to 0.87) and 0.80 (0.38 to 0.96), respectively; and of DECT, were 0.87 (0.79 to 0.93) and 0.84 (0.75 to 0.90), respectively.

conclusionsUS and DECT show promise for gout classification but the few studies to date have mostly been in patients with longstanding, established disease. The contribution of imaging over clinical features for gout classification criteria requires further examination.

Indexed as

GoutHumansMagnetic Resonance ImagingTomography, X-Ray ComputedUltrasonographyUric AcidUric AcidArthritisGoutUltrasonography

Identifiers

PMID24915980
PMCPMC4869978

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.