Evidence map›Paper›PMID 24915964›Full record

SynthesisBrain structure & function2015

The role of the right temporoparietal junction in attention and social interaction as revealed by ALE meta-analysis.

S C Krall, C Rottschy, E Oberwelland, D Bzdok, P T Fox, S B Eickhoff, G R Fink, K Konrad

Open access · greenAbstract readMeta-AnalysisReview
In one paragraph

Synthesis in Brain structure & function, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 12 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

178 citing papers in PubMed, 12 syntheses or guidelines pooled it, 355 citations in OpenAlex.

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  9. Resting-state functional reorganization in Parkinson's disease: An activation likelihood estimation meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2017
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  17. Kidney function and brain health: cognitive and structural signatures across cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

S C KrallInstitute of Neuroscience and Medicine (INM-3), Jülich Research Center, Jülich, Germany, s.krall@fz-juelich.de.
C Rottschy
E Oberwelland
D Bzdok
P T Fox
S B Eickhoff
G R Fink
K Konrad
Forschungszentrum Jülich · DEStadtwerke Jülich (Germany) · DESouth Texas Veterans Health Care System · USUniversity Hospital Cologne · DE

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
NIMH NIH HHS R01 MH074457
6 · The paper itself

Abstract

The right temporoparietal junction (rTPJ) is frequently associated with different capacities that to shift attention to unexpected stimuli (reorienting of attention) and to understand others' (false) mental state [theory of mind (ToM), typically represented by false belief tasks]. Competing hypotheses either suggest the rTPJ representing a unitary region involved in separate cognitive functions or consisting of subregions subserving distinct processes. We conducted activation likelihood estimation (ALE) meta-analyses to test these hypotheses. A conjunction analysis across ALE meta-analyses delineating regions consistently recruited by reorienting of attention and false belief studies revealed the anterior rTPJ, suggesting an overarching role of this specific region. Moreover, the anatomical difference analysis unravelled the posterior rTPJ as higher converging in false belief compared with reorienting of attention tasks. This supports the concept of an exclusive role of the posterior rTPJ in the social domain. These results were complemented by meta-analytic connectivity mapping (MACM) and resting-state functional connectivity (RSFC) analysis to investigate whole-brain connectivity patterns in task-constrained and task-free brain states. This allowed for detailing the functional separation of the anterior and posterior rTPJ. The combination of MACM and RSFC mapping showed that the posterior rTPJ has connectivity patterns with typical ToM regions, whereas the anterior part of rTPJ co-activates with the attentional network. Taken together, our data suggest that rTPJ contains two functionally fractionated subregions: while posterior rTPJ seems exclusively involved in the social domain, anterior rTPJ is involved in both, attention and ToM, conceivably indicating an attentional shifting role of this region.

Indexed as

Interpersonal RelationsAttentionBrain MappingHumansNeural PathwaysOccipital LobeParietal LobeTemporal LobeTheory of Mind

Identifiers

PMID24915964
PMCPMC4791048
OpenAlexW2043356371

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.