ArticleInternational urogynecology journal2014
Comparison of pelvic muscle architecture between humans and commonly used laboratory species.
Article in International urogynecology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Aging of Pelvic Floor in Animal Models: A Sistematic Review of Literature on the Role of the Extracellular Matrix in the Development of Pelvic Floor Prolapse.Frontiers in medicine · 2022Pooled it
- Animal models for pelvic organ prolapse: systematic review.International urogynecology journal · 2021Pooled it
- Assessment of the Impact of Vaginal Delivery on the Levator Ani Muscle Using Intravoxel Incoherent Motion MRI.International urogynecology journal · 2026Article
- Chapter 4.5: New Proposed Treatments for Pelvic Organ Prolapse.International urogynecology journal · 2026Review
- Repeated birth injuries lead to long-term pelvic floor muscle dysfunction in the preclinical rat model.American journal of obstetrics and gynecology · 2025Article
- Effect of lactation on postpartum pelvic floor muscle regeneration in preclinical model.npj women's health · 2025Article
- Mechanical Stress-Oxidative Stress Axis: Biological Basis in the Vaginal Wall and Pelvic Floor Muscles of Rats with Simulated Birth Injury.International urogynecology journal · 2024Article
- Sexual Dimorphism in the Architectural Design of Rat and Human Pelvic Floor Muscles.Journal of biomechanical engineering · 2024Article
- Proregenerative extracellular matrix hydrogel mitigates pathological alterations of pelvic skeletal muscles after birth injury.Science translational medicine · 2023Article
- Unique morphological architecture of the hamstring muscles and its functional relevance revealed by analysis of isolated muscle specimens and quantification of structural parameters.Journal of anatomy · 2023Article
- Current practice in animal models for pelvic floor dysfunction.International urogynecology journal · 2023Review
- Effects of the Oxytocin Hormone on Pelvic Floor Muscles in Pregnant Rats.Medicina (Kaunas, Lithuania) · 2023Article
- Muscle stem cells and fibro-adipogenic progenitors in female pelvic floor muscle regeneration following birth injury.NPJ Regenerative medicine · 2022Article
- Mechanisms governing protective pregnancy-induced adaptations of the pelvic floor muscles in the rat preclinical model.American journal of obstetrics and gynecology · 2022Article
- Animal Models and Alternatives in Vaginal Research: a Comparative Review.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Isolation of muscle stem cells from rat skeletal muscles.Stem cell research · 2020Article
- Uncovering changes in proteomic signature of rat pelvic floor muscles in pregnancy.American journal of obstetrics and gynecology · 2019Article
- Multimodal imaging assessment and histologic correlation of the female rat pelvic floor muscles' anatomy.Journal of anatomy · 2019Article
- Pelvic muscles' mechanical response to strains in the absence and presence of pregnancy-induced adaptations in a rat model.American journal of obstetrics and gynecology · 2018Article
- Structure-function relationship of the human external anal sphincter.International urogynecology journal · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
introduction and hypothesisPelvic floor muscles (PFM) are deleteriously affected by vaginal birth, which contributes to the development of pelvic floor disorders. To mechanistically link these events, experiments using animal models are required, as access to human PFM tissue is challenging. In choosing an animal model, a comparative study of PFM design is necessary, since gross anatomy alone is insufficient to guide the selection.
methodsHuman PFM architecture was measured using micromechanical dissection and then compared with mouse (n = 10), rat (n = 10), and rabbit (n = 10) using the Architectural Difference Index (ADI) (parameterizing a combined measure of sarcomere length-to-optimal-sarcomere ratio, fiber-to-muscle-length ratio, and fraction of total PFM mass and physiological cross-sectional area (PCSA) contributed by each muscle). Coccygeus (C), iliocaudalis (IC), and pubocaudalis (PC) were harvested and subjected to architectural measurements. Parameters within species were compared using repeated measures analysis of variance (ANOVA) with post hoc Tukey's tests. The scaling relationships of PFM across species were quantified using least-squares regression of log-10-transformed variables.
resultsBased on the ADI, rat was found to be the most similar to humans (ADI = 2.5), followed by mouse (ADI = 3.3). When animals' body mass was regressed against muscle mass, muscle length, fiber length, and PCSA scaling coefficients showed a negative allometric relationship or smaller increase than predicted by geometric scaling.
conclusionIn terms of muscle design among commonly used laboratory animals, rat best approximates the human PFM, followed by mouse. Negative allometric scaling of PFM architectural parameters is likely due to the multifaceted function of these muscles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.