Evidence map›Paper›PMID 24915299›Full record

ArticleNature communications2014

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.

Christian Elabd, Wendy Cousin, Pavan Upadhyayula, Robert Y Chen, Marc S Chooljian, Ju Li, Sunny Kung, Kevin P Jiang, Irina M Conboy

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 227 papers.

0numbers the graph read from it
0cells of the map it votes in
227citing papers in PubMed
40.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

227 citing papers in PubMed, 415 citations in OpenAlex.

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  7. Microbial lysate upregulates host oxytocin.Brain, behavior, and immunity · 2017
    Trial
  8. Article
  9. Role of Oxytocin in Obesity.Current diabetes reports · 2026
    Review
  10. Article
  11. Article
  12. Article
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  15. Parabiosis, Assembloids, Organoids (PAO).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  16. Article
  17. Article
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  19. Article
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167 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Christian Elabd *Department of Bioengineering, Stem Cell Center, and QB3 Institute, UC Berkeley, Berkeley, CA 94720, USA; University of California, Berkeley B107B Stanley Hall #1762 Berkeley, CA 94720-1762.
Wendy Cousin *Department of Bioengineering, Stem Cell Center, and QB3 Institute, UC Berkeley, Berkeley, CA 94720, USA; University of California, Berkeley B107B Stanley Hall #1762 Berkeley, CA 94720-1762.
Pavan UpadhyayulaDepartment of Bioengineering, Stem Cell Center, and QB3 Institute, UC Berkeley, Berkeley, CA 94720, USA; University of California, Berkeley B107B Stanley Hall #1762 Berkeley, CA 94720-1762.
Robert Y ChenDepartment of Bioengineering, Stem Cell Center, and QB3 Institute, UC Berkeley, Berkeley, CA 94720, USA; University of California, Berkeley B107B Stanley Hall #1762 Berkeley, CA 94720-1762.
Marc S ChooljianDepartment of Bioengineering, Stem Cell Center, and QB3 Institute, UC Berkeley, Berkeley, CA 94720, USA; University of California, Berkeley B107B Stanley Hall #1762 Berkeley, CA 94720-1762.
Ju LiDepartment of Bioengineering, Stem Cell Center, and QB3 Institute, UC Berkeley, Berkeley, CA 94720, USA; University of California, Berkeley B107B Stanley Hall #1762 Berkeley, CA 94720-1762.
Sunny KungDepartment of Bioengineering, Stem Cell Center, and QB3 Institute, UC Berkeley, Berkeley, CA 94720, USA; University of California, Berkeley B107B Stanley Hall #1762 Berkeley, CA 94720-1762.
Kevin P JiangDepartment of Bioengineering, Stem Cell Center, and QB3 Institute, UC Berkeley, Berkeley, CA 94720, USA; University of California, Berkeley B107B Stanley Hall #1762 Berkeley, CA 94720-1762.
Irina M ConboyDepartment of Bioengineering, Stem Cell Center, and QB3 Institute, UC Berkeley, Berkeley, CA 94720, USA; University of California, Berkeley B107B Stanley Hall #1762 Berkeley, CA 94720-1762.
University of California, Berkeley · US

Funding

Effects of the systemic environment on muscle agingR01AG027252 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONBOY, IRINA M · 2007 to 2012
$1.7M
NIA NIH HHS AG 027252NIA NIH HHS R01 AG027252
6 · The paper itself

Abstract

The regenerative capacity of skeletal muscle declines with age. Previous studies suggest that this process can be reversed by exposure to young circulation; however, systemic age-specific factors responsible for this phenomenon are largely unknown. Here we report that oxytocin--a hormone best known for its role in lactation, parturition and social behaviours--is required for proper muscle tissue regeneration and homeostasis, and that plasma levels of oxytocin decline with age. Inhibition of oxytocin signalling in young animals reduces muscle regeneration, whereas systemic administration of oxytocin rapidly improves muscle regeneration by enhancing aged muscle stem cell activation/proliferation through activation of the MAPK/ERK signalling pathway. We further show that the genetic lack of oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia. Considering that oxytocin is an FDA-approved drug, this work reveals a potential novel and safe way to combat or prevent skeletal muscle ageing.

Indexed as

MAP Kinase Signaling SystemAgingAnimalsCell Culture TechniquesCell ProliferationHomeostasisMiceMuscle Fibers, SkeletalMuscle, SkeletalOxytocinRegenerationSarcopeniaSatellite Cells, Skeletal MuscleStem CellsOxytocin

Identifiers

PMID24915299
PMCPMC4512838
OpenAlexW2169617007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.