ArticleInorganic chemistry2014
Addition of a second binding site increases the dynamic range but alters the cellular localization of a red fluorescent probe for mobile zinc.
Article in Inorganic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Tuning SBDs as Endoplasmic Reticulum Self-Targeting Fluorophores and Its Application for ZnChemical & biomedical imaging · 2025Article
- Recent endeavors on molecular imaging for mapping metals in biology.Biophysics reports · 2020Article
- Subcellular localised small molecule fluorescent probes to image mobile ZnChemical science · 2020Review
- Reaction-Based Probes for Imaging Mobile Zinc in Live Cells and Tissues.ACS sensors · 2016Article
- Peptide Targeting of Fluorescein-Based Sensors to Discrete Intracellular Locales.Chemical science · 2014Article
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3 authors.
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Abstract
We report the synthesis and photophysical properties of ZBR4 and ZR1, two resorufin-based ditopic probes for mobile zinc. Upon binding Zn(2+), the sensors display 14- and 41-fold enhancements of their red fluorescence emission, respectively. In contrast to ZR1 and other members of the ZBR family, which accumulate in the endoplasmic reticulum, ZBR4 spontaneously localizes to the mitochondria of HeLa cells. The modular approach in designing the constructs facilitates a homologation strategy aimed at tuning the zinc-binding and intracellular targeting properties of future probes.
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