Trial reportInfection control and hospital epidemiology2014
Preventing surgical site infections: a randomized, open-label trial of nasal mupirocin ointment and nasal povidone-iodine solution.
Trial report in Infection control and hospital epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 54 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Surgical Site Infections: Effectiveness of Nasal Povidone-Iodine
An Investigation of Novel Technology to Bring Genomic Analysis to the Patient Bedside to Systematically Track and Report on ESKAPE Bacterial Transmission in Today's Operating Room Environments
Improving Case Selection for Perioperative S. Aureus Transmission Surveillance to Reduce Surgical Site Infections
Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Nasal decolonization of Staphylococcus aureus and the risk of surgical site infection after surgery: a meta-analysis.Annals of clinical microbiology and antimicrobials · 2020Pooled it
- Nasal decontamination for the prevention of surgical site infection in Staphylococcus aureus carriers.The Cochrane database of systematic reviews · 2017Pooled it
- Antibiotics and antiseptics for preventing infection in people receiving revision total hip and knee prostheses: a systematic review of randomized controlled trials.BMC infectious diseases · 2016Pooled it
- Systematic review and meta-analysis of randomized controlled trials of antibiotics and antiseptics for preventing infection in people receiving primary total hip and knee prostheses.Antimicrobial agents and chemotherapy · 2015Pooled it
- Survey of hemodialysis patients' knowledge of their infection risk and acceptability of an intranasal decolonization intervention.Infection control and hospital epidemiology · 2026Trial
- Comparison of the Efficacy of Povidone-Iodine with Mupirocin in DecolonizingInfectious disorders drug targets · 2025Trial
- Decolonization in Nursing Homes to Prevent Infection and Hospitalization.The New England journal of medicine · 2023Trial
- Trial
- The Effect of Improving Basic Preventive Measures in the Perioperative Arena on Staphylococcus aureus Transmission and Surgical Site Infections: A Randomized Clinical Trial.JAMA network open · 2020Trial
- Trial
- Efficacy of skin and nasal povidone-iodine preparation against mupirocin-resistant methicillin-resistant Staphylococcus aureus and S. aureus within the anterior nares.Antimicrobial agents and chemotherapy · 2015Trial
- Tolerability and effectiveness of povidone-iodine or mupirocin versus saline sinus irrigations for chronic rhinosinusitis.American journal of otolaryngologyTrial
- Universal decolonization for methicillin-resistantPublic health in practice (Oxford, England) · 2026Article
- Barriers and Enablers in Home-Based Staphylococcus aureus Decolonisation Among Orthopaedic Surgery Patients: A Qualitative Study.Nursing open · 2026Article
- Intranasal povidone-iodine concentration and olfactory recovery after endoscopic endonasal pituitary surgery.Pituitary · 2026Article
- Collagen binding adhesin restricts Staphylococcus aureus skin infection.Nature communications · 2026Article
- Nasal decolonization in total joint arthroplasty: current state of evidence.Journal of bone and joint infection · 2026Review
- Periprosthetic joint infection after arthroplasty: advances and future prospects.Journal of orthopaedic surgery and research · 2025Review
- Intranasal Testing and Treatment forJournal of the Pediatric Orthopaedic Society of North America · 2025Article
- Impact of Povidone Application to Nares in Addition to Chlorhexidine Bath in Critically Ill Patients on Nosocomial Bacteremia and Central Line Blood Stream Infection.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundTreatment of Staphylococcus aureus colonization before surgery reduces risk of surgical site infection (SSI). The regimen of nasal mupirocin ointment and topical chlorhexidine gluconate is effective, but cost and patient compliance may be a barrier. Nasal povidone-iodine solution may provide an alternative to mupirocin.
methodsWe conducted an investigator-initiated, open-label, randomized trial comparing SSI after arthroplasty or spine fusion in patients receiving topical chlorhexidine wipes in combination with either twice daily application of nasal mupirocin ointment during the 5 days before surgery or 2 applications of povidone-iodine solution into each nostril within 2 hours of surgical incision. The primary study end point was deep SSI within the 3 months after surgery.
resultsIn the modified intent-to-treat analysis, a deep SSI developed after 14 of 855 surgical procedures in the mupirocin group and 6 of 842 surgical procedures in the povidone-iodine group (P = .1); S. aureus deep SSI developed after 5 surgical procedures in the mupirocin group and 1 surgical procedure in the povidone-iodine group (P = .2). In the per protocol analysis, S. aureus deep SSI developed in 5 of 763 surgical procedures in the mupirocin group and 0 of 776 surgical procedures in the povidone-iodine group (P = .03).
conclusionsNasal povidone-iodine may be considered as an alternative to mupirocin in a multifaceted approach to reduce SSI.
trial registrationClinicalTrials.gov identifier: NCT01313182.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.