ArticleAnnals of the American Thoracic Society2014
Fungal exposure, atopy, and asthma exacerbations in Puerto Rican children.
Article in Annals of the American Thoracic Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33.The Journal of allergy and clinical immunology · 2015Trial
- Exposure to structurally unique β-d-glucans differentially affects inflammatory responses in male mouse lungs.Physiological reports · 2024Article
- Early life exposures of childhood asthma and allergies-an epidemiologic perspective.Frontiers in allergy · 2024Article
- Impact of Hurricane Maria on mold levels in the homes of Piñones, Puerto Rico.Air quality, atmosphere, & health · 2022Article
- Bedroom Allergen Exposure Beyond House Dust Mites.Current allergy and asthma reports · 2018Review
- Identification of Immunoglobulin E-Binding Proteins of the Xerophilic Fungus Aspergillus penicillioides Crude Mycelial Mat Extract and Serological Reactivity Assessment in Subjects with Different Allergen Reactivity Profiles.International archives of allergy and immunology · 2018Article
- Genome-wide interaction study of dust mite allergen on lung function in children with asthma.The Journal of allergy and clinical immunology · 2017Article
- Ambient Air Pollution, Meteorological Factors and Outpatient Visits for Eczema in Shanghai, China: A Time-Series Analysis.International journal of environmental research and public health · 2016Article
- Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children.The Journal of allergy and clinical immunology · 2016Article
- Characterization of the bacterial and fungal microbiome in indoor dust and outdoor air samples: a pilot study.Environmental science. Processes & impacts · 2016Article
- Particularities of allergy in the Tropics.The World Allergy Organization journal · 2016Review
- Exposure to positively- and negatively-charged plasma cluster ions impairs IgE-binding capacity of indoor cat and fungal allergens.The World Allergy Organization journal · 2016Article
- Child maltreatment and pediatric asthma: a review of the literature.Asthma research and practice · 2016Review
- Mold populations and dust mite allergen concentrations in house dust samples from across Puerto Rico.International journal of environmental health research · 2016Article
- Asthma in Latin America.Thorax · 2015Review
- Environmental mold and mycotoxin exposures elicit specific cytokine and chemokine responses.PloS one · 2015Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundGlucan is a component of the fungal cell wall that is used as a marker of fungal exposure. Little is known about indoor glucan, atopy, and asthma exacerbations among children living in tropical environments such as Puerto Rico. Our objective was to examine whether glucan exposure is associated with degree of atopy or visits to the emergency department (ED)/urgent care for asthma in Puerto Rican children.
methodsThis was a cross-sectional study of 317 children aged 6 to 14 years with (cases, n = 160) and without (control subjects, n = 157) asthma in San Juan, Puerto Rico. Our primary outcomes were the number of positive skin tests to allergens (range, 0-15) and (in cases only) having had at least one visit to the ED/urgent care for asthma in the prior year. Levels of glucan, endotoxin, peptidoglycan, and five allergens (Der p 1, Bla g 2, Fel d 1, Can f 1, and Mus m 1) were measured in samples of house dust. Linear or logistic regression was used for the multivariate analysis. MEASUREMENTS AND MAIN
resultsIn a multivariate analysis adjusting for case-control status, mouse allergen, and other covariates, children exposed to glucan levels in the second and third quartiles had approximately two more positive skin tests than those in the lowest quartile (P < 0.01 in both instances). Among children with asthma, exposure to the highest quartile of glucan was associated with nearly ninefold greater odds of one or more visits to the ED/urgent care for asthma (95% confidence interval for adjusted odds ratio, 2.7-28.4; P < 0.001).
conclusionsOur results suggest that indoor fungal exposure leads to an increased degree of atopy and visits to the ED/urgent care for asthma in Puerto Rican children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.