ArticlePloS one2014
High seroprevalence of human herpesviruses in HIV-infected individuals attending primary healthcare facilities in rural South Africa.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03092505 (Herpesviruses Reactivation In Hiv-Infected Women Initiating ART), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Herpesviruses Reactivation In Hiv-Infected Women Initiating ART (HERA)
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Varicella zoster virus-associated morbidity and mortality in Africa - a systematic review.BMC infectious diseases · 2017Pooled it
- Article
- Fulminant Yersinia Pestis Infection in a Known HIV-Positive Patient: A Case Report of Identification in Nigeria 2024.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Herpesviruses Reactivation and Systemic Inflammation Before and After Initiating Antiretroviral Therapy Among Women with HIV in Rakai, Uganda.Open forum infectious diseases · 2025Article
- Reduced anti-viral IgG repertoire in HIV-exposed but uninfected infants compared to HIV-unexposed infants.iScience · 2024Article
- The Burden of Epstein-Barr Virus (EBV) and Its Determinants among Adult HIV-Positive Individuals in Ethiopia.Viruses · 2023Article
- Detection of Human Herpesviruses in Sera and Saliva of Asymptomatic HIV-Infected Individuals Using Multiplex RT-PCR DNA Microarray.Pathogens (Basel, Switzerland) · 2023Article
- Cytomegalovirus retinitis and antiretroviral treatment: A fifteen year experience.Southern African journal of HIV medicine · 2022Article
- Multisystem cytomegalovirus end-organ disease in a patient with advanced HIV.Southern African journal of infectious diseases · 2022Article
- Seroprevalence of Human Herpesvirus Infections in Newly Diagnosed HIV-Infected Key Populations in Dar es Salaam, Tanzania.International journal of microbiology · 2021Article
- Kaposi's Sarcoma-Associated Herpesvirus, but Not Epstein-Barr Virus, Co-infection Associates With Coronavirus Disease 2019 Severity and Outcome in South African Patients.Frontiers in microbiology · 2021Article
- Cytomegalovirus-associated esophageal stricture as a manifestation of the immune reconstitution inflammatory syndrome.IDCases · 2020Article
- Article
- Chronic HIV-1 Infection Alters the Cellular Distribution of FcγRIIIa and the Functional Consequence of the FcγRIIIa-F158V Variant.Frontiers in immunology · 2019Article
- Herpesvirus-encoded microRNAs detected in human gingiva alter host cell transcriptome and regulate viral infection.Biochimica et biophysica acta. Gene regulatory mechanisms · 2018Article
- HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution.PloS one · 2017Article
- Elevated humoral response to cytomegalovirus in HIV-infected individuals with poor CD4+ T-cell immune recovery.PloS one · 2017Article
- Clinical and corneal microbial profile of infectious keratitis in a high HIV prevalence setting in rural South Africa.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- HSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates.JCI insight · 2016Article
- Human cytomegalovirus (CMV) in Africa: a neglected but important pathogen.Journal of virus eradication · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Seroprevalence data of human herpesviruses (HHVs) are limited for sub-Saharan Africa. These are important to provide an indication of potential burden of HHV-related disease, in particular in human immunodeficiency virus (HIV)-infected individuals who are known to be at increased risk of these conditions in the Western world. In this cross-sectional study among 405 HIV-infected and antiretroviral therapy naïve individuals in rural South Africa the seroprevalence of HHVs was: herpes simplex virus type 1 (HSV-1) (98%), herpes simplex virus type 2 (HSV-2) (87%), varicella zoster virus (VZV) (89%), and 100% for both Epstein-Barr virus (EBV) and cytomegalovirus (CMV). Independent factors associated with VZV seropositivity were low educational status and having children. Lack of in-house access to drinking water was independently associated with positive HSV-1 serostatus, whereas Shangaan ethnicity was associated with HSV-2 seropositivity. Increasing age was associated with higher IgG titres to both EBV and CMV, whereas CD4 cell count was negatively associated with EBV and CMV IgG titres. Moreover, IgG titres of HSV-1 and 2, VZV and CMV, and CMV and EBV were positively correlated. The high HHV seroprevalence emphasises the importance of awareness of these viral infections in HIV-infected individuals in South Africa.
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