ArticleDevelopmental cell2014
A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation.
Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Microtubule-templated actin assembly by septin9 drives apical expansion of epithelial cells.bioRxiv : the preprint server for biology · 2026Article
- The Drosophila larval salivary gland, a simple and elegant model system to understand secretory organ development and function.Current opinion in insect science · 2026Review
- Membrane Trafficking in Psychiatric Disorders: Bridging Cellular Dysfunction and Mental Health-A Narrative Review.Molecular neurobiology · 2025Review
- Arc controls organ architecture through modulation of Crb and MyoII.The Journal of cell biology · 2025Article
- Supracellular actomyosin assemblies: master coordinators of development.Development (Cambridge, England) · 2025Review
- IsJournal of developmental biology · 2025Review
- Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation.Nature communications · 2025Article
- Review
- Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation.eLife · 2025Article
- Single-cell analysis of the early Drosophila salivary gland reveals that morphogenetic control involves both the induction and exclusion of gene expression programs.PLoS biology · 2025Article
- Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the earlyeLife · 2024Article
- Mechanical state transitions in the regulation of tissue form and function.Nature reviews. Molecular cell biology · 2024Review
- β-H-Spectrin is a key component of an apical-medial hub of proteins during cell wedging in tube morphogenesis.Journal of cell science · 2024Article
- Dynamic interplay of microtubule and actomyosin forces drive tissue extension.Nature communications · 2024Article
- MAP3K1 regulates female reproductive tract development.Disease models & mechanisms · 2024Article
- Programmed disassembly of a microtubule-based membrane protrusion network coordinates 3D epithelial morphogenesis in Drosophila.The EMBO journal · 2024Article
- Article
- α-Spectrin regulates cell shape changes during disassembly of microtubule-driven protrusions inmicroPublication biology · 2024Article
- Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling.Developmental cell · 2023Article
- Architecture of the cortical actomyosin network driving apical constriction in C. elegans.The Journal of cell biology · 2023Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex tissues during development. Important roles for actomyosin during tissue morphogenesis have been identified, but the role of the microtubule cytoskeleton is less clear. Here, we show that during tubulogenesis of the salivary glands in the fly embryo, the microtubule cytoskeleton undergoes major rearrangements, including a 90° change in alignment relative to the apicobasal axis, loss of centrosomal attachment, and apical stabilization. Disruption of the microtubule cytoskeleton leads to failure of apical constriction in placodal cells fated to invaginate. We show that this failure is due to loss of an apical medial actomyosin network whose pulsatile behavior in wild-type embryos drives the apical constriction of the cells. The medial actomyosin network interacts with the minus ends of acentrosomal microtubule bundles through the cytolinker protein Shot, and disruption of Shot also impairs apical constriction.
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