ArticleWorld journal of gastroenterology2014
Simple animal model of Helicobacter pylori infection.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Manuka honey as a multifunctional therapeutic against Helicobacter pylori: from chemical profiling to in vitro potency and in vivo gastroprotective efficacy.BMC complementary medicine and therapies · 2026Article
- Regulatory Effects of Probiotics on Anxiety and Depression-Like Behaviors in H. pylori-Infected Rats.Probiotics and antimicrobial proteins · 2026Article
- The effects of postbiotics and glycyrrhetinic acid on immune response and inflammation-related genes during H. pylori eradication therapy.BMC microbiology · 2025Article
- Establishment of an intragastric surgical model using C57BL/6 mice to study the vaccine efficacy of OMV-based immunogens against Helicobacter pylori.Biology open · 2025Article
- Unveiling the Potency of Gardenia Extract AgainstBiomedicines · 2025Article
- Synergic Effects of Curcumin, Licorice, and Endoscopic Photodynamic Therapy Against Helicobacter Pylori by Modulating the NF-Κb Signaling Pathway.Iranian journal of biotechnology · 2025Article
- Research advances of the establishment and characterization ofFrontiers in microbiology · 2025Review
- Brazilian Red Propolis Presents Promising Anti-Molecules (Basel, Switzerland) · 2022Article
- Aspartate α-decarboxylase a new therapeutic target in the fight againstFrontiers in microbiology · 2022Article
- Gastric histopathological features after the administration of omeprazole, amoxicillin, and clarithromycin in gastritisJournal of advanced veterinary and animal research · 2021Article
- NovelVeterinary world · 2021Article
- Genistein attenuated gastric inflammation and apoptosis in Helicobacter pylori-induced gastropathy in rats.BMC gastroenterology · 2020Article
- The effect ofVeterinary world · 2020Article
- The effect of snakehead fish extract supplementation to first-line eradication regimen on macrophage migration inhibitory factor (MIF) expression in rats induced byJournal of advanced veterinary and animal research · 2020Article
- UPLC-Q-TOF/MS-Based Serum and Urine Metabonomics Study on the Ameliorative Effects of Palmatine onFrontiers in pharmacology · 2020Article
- The Skeletal Effects of Short-Term Triple Therapy in a Rat Model of Gastric Ulcer Induced byDrug design, development and therapy · 2020Article
- Integrative and Conjugative Elements ofFrontiers in cellular and infection microbiology · 2020Article
- Evaluating the Inhibitory Effects of Probiotic Bacteria and Propolis Extracts on the Growth and Histopathological Changes in Gastric Tissues ofIranian journal of pharmaceutical research : IJPRArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori (H. pylori) has become accepted as a human pathogen for the development of gastritis and gastroduodenal ulcer. To develop a simple rat model of chronic H. pylori infection, male Sprague-Dawley rats were pretreated with streptomycin suspended in tap water (5 mg/mL) for 3 d. The rats were inoculated by gavage at 1 mL/rat with H. pylori suspension (5 × 10(8)-5 × 10(10) CFU/mL) twice daily at an interval of 4 h for three consecutive days. Two weeks after inoculation, rats were sacrificed and the stomachs were removed. Antral biopsies were performed for urease test and the stomachs were taken for histopathology. Successful H. pylori inoculation was defined as a positive urease test and histopathology. We reported a 69.8%-83.0% success rate for H. pylori infection using the urease test, and hematoxylin and eosin staining confirmed the results. Histopathological analysis detected bacteria along the mucous lining of the surface epithelium and crypt lumen and demonstrated mild to moderate gastric inflammation in successfully inoculated rats. We developed a simple rat model of chronic H. pylori infection for research into gastric microcirculatory changes and therapy with plant products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.