ArticleWorld journal of gastroenterology2014
Late biliary complications in human alveolar echinococcosis are associated with high mortality.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Magnetic Resonance Imaging Features of Hepatic Hydatid Disease: A Pictorial Review with Emphasis on Atypical Presentations and Differential Diagnosis.Diagnostics (Basel, Switzerland) · 2026Review
- The Role of Interventional Radiology for the Treatment of Liver CE and AE Lesions: Current Concepts.Visceral medicine · 2025Review
- Clinical, Diagnostical, and Epidemiological Findings at First Diagnosis of Alveolar Echinococcosis: A Single-Center Cohort Study.Visceral medicine · 2025Article
- The initial stage of alveolar echinococcosis is a diagnostic challenge: a case report.Journal of medical case reports · 2025Article
- Comparison of ultrasonographic features between two types of hepatic echinococcosis and hepatoblastoma in children.Frontiers in pediatrics · 2025Article
- Pictorial review of hepatic echinococcosis: Ultrasound imaging and differential diagnosis.World journal of gastroenterology · 2024Review
- Role of the radiologist in the diagnosis and management of the two forms of hepatic echinococcosis.Insights into imaging · 2022Review
- Emerging human alveolar echinococcosis in Hungary (2003-2018): a retrospective case series analysis from a multi-centre study.BMC infectious diseases · 2021Article
- Recent advances in surgical strategies for alveolar echinococcosis of the liver.Surgery today · 2020Review
- Evaluation of intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis.World journal of gastroenterology · 2020Article
- Surgical treatment strategies for hepatic alveolar echinococcosis.Food and waterborne parasitology · 2019Article
- Echinococcosis: Advances in the 21st Century.Clinical microbiology reviews · 2019Review
- Case Report: Role of Interventional Radiology in the Management of Patients with Alveolar Echinococcus: Successful Management of Three Cases.The American journal of tropical medicine and hygiene · 2018Article
- Risk factors and a simple model for predicting bile leakage after radical hepatectomy in patients with hepatic alveolar echinococcosis.Medicine · 2017Article
- Secondary Sclerosing Cholangitis: a Review of Recent Literature.Current gastroenterology reports · 2017Review
- Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study.World journal of gastroenterology · 2015Article
- Outcome after Discontinuing Long-Term Benzimidazole Treatment in 11 Patients with Non-resectable Alveolar Echinococcosis with Negative FDG-PET/CT and Anti-EmII/3-10 Serology.PLoS neglected tropical diseases · 2015Observational
- Non-surgical and non-chemical attempts to treat echinococcosis: do they work?Parasite (Paris, France) · 2014Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis (AE) under long-term chemotherapy with benzimidazoles.
methodsRetrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE. We compared characteristics of patients with and without biliary complications, analyzed potential risk factor for biliary complications and performed survival analyses.
resultsNinety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy, of which 26 (28%) patients developed late biliary complications. These patients had a median age of 55.5 (35.5-65) years at diagnosis of AE and developed biliary complications after 15 (8.25-19) years of chemotherapy. The most common biliary complications during long-term chemotherapy were late-onset cholangitis (n = 14), sclerosing cholangitis-like lesions (n = 8), hepatolithiasis (n = 5), affection of the common bile duct (n = 7) and secondary biliary cirrhosis (n = 7). Thirteen of the 26 patients had undergone surgery (including 12 resections) before chemotherapy. Previous surgery was a risk factor for late biliary complications in linear regression analysis (P = 0.012).
conclusionLate biliary complications can be observed in nearly one third of patients with non-resectable AE, with previous surgery being a potential risk factor. After the occurrence of late biliary complications, the median survival is only 3 years, suggesting that late biliary complications indicate a poor prognostic outcome.
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