ReviewWorld journal of gastroenterology2014
Autophagy in hepatitis C virus-host interactions: potential roles and therapeutic targets for liver-associated diseases.
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Autophagy in the liver.Autophagy reports · 2026Review
- Functional Role of Hepatitis C Virus NS5A in the Regulation of Autophagy.Pathogens (Basel, Switzerland) · 2024Review
- Tomato chlorosis virus p22 interacts with NbBAG5 to inhibit autophagy and regulate virus infection.Molecular plant pathology · 2023Article
- The molecular regulation of autophagy in antimicrobial immunity.Journal of molecular cell biology · 2022Article
- The Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis.Frontiers in cellular and infection microbiology · 2021Review
- Enterovirus 71 VP1 Protein Regulates Viral Replication in SH-SY5Y Cells via the mTOR Autophagy Signaling Pathway.Viruses · 2019Article
- Autophagy Promotes Porcine Parvovirus Replication and Induces Non-Apoptotic Cell Death in Porcine Placental Trophoblasts.Viruses · 2019Article
- The Right Liver Lobe Size/Albumin Concentration Ratio in Identifying Esophageal Varices among Patients with Liver Cirrhosis.Middle East journal of digestive diseases · 2019Article
- Autophagy: The multi-purpose bridge in viral infections and host cells.Reviews in medical virology · 2018Review
- Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy.Frontiers in immunology · 2018Article
- X protein variants of the autochthonous Latin American hepatitis B virus F genotype promotes human hepatocyte death by the induction of apoptosis and autophagy.Virus research · 2017Article
- Dual Roles of Two Isoforms of Autophagy-related Gene ATG10 in HCV-Subgenomic replicon Mediated Autophagy Flux and Innate Immunity.Scientific reports · 2017Article
- Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.FEBS letters · 2016Review
- Emerging roles of interferon-stimulated genes in the innate immune response to hepatitis C virus infection.Cellular & molecular immunology · 2016Review
- HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis.Oxidative medicine and cellular longevity · 2016Review
- Hepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagy.World journal of gastroenterology · 2015Review
- The role of autophagy in microbial infection and immunity.ImmunoTargets and therapy · 2015Review
- Autophagy and apoptosis in liver injury.Cell cycle (Georgetown, Tex.) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy is a lysosome-associated, degradative process that catabolizes cytosolic components to recycle nutrients for further use and maintain cell homeostasis. Hepatitis C virus (HCV) is a major cause of chronic hepatitis, which often leads to end-stage liver-associated diseases and is a significant burden on worldwide public health. Emerging lines of evidence indicate that autophagy plays an important role in promoting the HCV life cycle in host cells. Moreover, the diverse impacts of autophagy on a variety of signaling pathways in HCV-infected cells suggest that the autophagic process is required for balancing HCV-host cell interactions and involved in the pathogenesis of HCV-related liver diseases. However, the detailed molecular mechanism underlying how HCV activates autophagy to benefit viral growth is still enigmatic. Additionally, how the autophagic response contributes to disease progression in HCV-infected cells remains largely unknown. Hence, in this review, we overview the interplay between autophagy and the HCV life cycle and propose possible mechanisms by which autophagy may promote the pathogenesis of HCV-associated chronic liver diseases. Moreover, we outline the related studies on how autophagy interplays with HCV replication and discuss the possible implications of autophagy and viral replication in the progression of HCV-induced liver diseases, e.g., steatosis and hepatocellular carcinoma. Finally, we explore the potential therapeutics that target autophagy to cure HCV infection and its related liver diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.