ArticlePharmacognosy magazine2014
Antiasthmatic effects of schizandrae fructus extract in mice with asthma.
Article in Pharmacognosy magazine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways.Molecular medicine reports · 2021Article
- Peculiarities of vascular endothelial growth factor of oral cavity in atopic condition VEGF of oral cavity in atopic condition.Interventional medicine & applied science · 2021Article
- Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/Molecules (Basel, Switzerland) · 2021Article
- Gomisin M2 Inhibits Mast Cell-Mediated Allergic InflammationFrontiers in pharmacology · 2019Article
- Pharmacokinetics of Schizandrin and Its Pharmaceutical Products Assessed Using a Validated LC-MS/MS Method.Molecules (Basel, Switzerland) · 2018Article
- Schisandrin A inhibits dengue viral replication via upregulating antiviral interferon responses through STAT signaling pathway.Scientific reports · 2017Article
- Current knowledge ofPhytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2017Review
- Deoxyschizandrin suppresses dss-induced ulcerative colitis in mice.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSchizandrae fructus (SF), the fruit of Schisandra chinensis, has been used for the treatment of cough, wheezing, dry mouth, hepatitis, cardiovascular disease, and as a tonic and astringent in China, Japan, and Korea.
objectiveInvestigation of the antiasthmatic effects of SF. MATERIALS AND
methodsWe investigated the effects of SF on airway hyperresponsiveness (AHR) to methacholine, production levels of antigen-specific antibodies, and histopathological changes in the lung tissue in a mouse model (Balb/c) of asthma induced by repeated intranasal instillation of an antigen.
resultsSF lowered AHR to methacholine (P < 0.05), antigen-specific immunoglobulin E (IgE) level (P < 0.01), and immune cell infiltration in mice with asthma. Prednisolone (PD) effectively decreased AHR (P < 0.01), total antibody (P < 0.01) and IgE (P < 0.01) levels, and immune cell infiltration. SF and PD did not affect the levels of antigen-specific IgG1 and IgG2a antibodies.
conclusionOur data suggest that SF has possible application as an antiasthmatic drug. We also suggest that SF could be used as a complementary or alternative medicine to glucocorticoids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.